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dc.rights.licenseopenen_US
dc.contributor.authorBIENVENU, Thomas C. M.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDEJEAN, Cyril
dc.contributor.authorJERCOG, Daniel
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
IDREF: 069471851
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLEMOINE, Mael
IDREF: 050536214
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorHERRY, Cyril
dc.date.accessioned2021-10-19T15:15:37Z
dc.date.available2021-10-19T15:15:37Z
dc.date.issued2021-08-04
dc.identifier.issn0896-6273en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112819
dc.description.abstractEnTranslational research on post-traumatic stress disorder (PTSD) has produced limited improvements in clinical practice. Fear conditioning (FC) is one of the dominant animal models of PTSD. In fact, FC is used in many different ways to model PTSD. The variety of FC-based models is ill defined, creating confusion and conceptual vagueness, which in turn impedes translation into the clinic. This article takes a historical and conceptual approach to provide a comprehensive picture of current research and help reorient the research focus. This work historically reviews the variety of models that have emerged from the initial association of PTSD with FC, highlighting conceptual pitfalls that have limited the translation of animal research into clinical advances. We then provide some guidance on how future translational research could benefit from conceptual and technological improvements to translate basic findings in patients. This objective will require transdisciplinary approaches and should involve physicians, engineers, philosophers, and neuroscientists.
dc.language.isoENen_US
dc.title.enThe advent of fear conditioning as an animal model of post-traumatic stress disorder: Learning from the past to shape the future of PTSD research
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neuron.2021.05.017en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34146470en_US
bordeaux.journalNeuronen_US
bordeaux.page2380-2397en_US
bordeaux.volume109en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue15en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03386102
hal.version1
hal.date.transferred2021-10-19T15:15:46Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuron&rft.date=2021-08-04&rft.volume=109&rft.issue=15&rft.spage=2380-2397&rft.epage=2380-2397&rft.eissn=0896-6273&rft.issn=0896-6273&rft.au=BIENVENU,%20Thomas%20C.%20M.&DEJEAN,%20Cyril&JERCOG,%20Daniel&AOUIZERATE,%20Bruno&LEMOINE,%20Mael&rft.genre=article


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