CB1R-dependent regulation of astrocyte physiology and astrocyte-neuron interactions
| dc.rights.license | open | en_US |
| dc.contributor.author | COVELO FERNANDEZ, Ana | |
| dc.contributor.author | ERASO-PICHOT, Abel | |
| dc.contributor.author | FERNANDEZ-MONCADA, Ignacio | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | SERRAT, Roman | |
| dc.contributor.author | MARSICANO, Giovanni | |
| dc.date.accessioned | 2021-10-19T14:37:26Z | |
| dc.date.available | 2021-10-19T14:37:26Z | |
| dc.date.issued | 2021-09-01 | |
| dc.identifier.issn | 0028-3908 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112816 | |
| dc.description.abstractEn | The endocannabinoid system (ECS) is involved in a variety of brain functions, mainly through the activation of the type-1 cannabinoid receptors (CB1R). CB1R are highly expressed throughout the brain at different structural, cellular and subcellular locations and its activity and expression levels have a direct impact in synaptic activity and behavior. In the last few decades, astrocytes have arisen as active players of brain physiology through their participation in the tripartite synapse and through their metabolic interaction with neurons. Here, we discuss some of the mechanisms by which astroglial CB1R at different subcellular locations, regulate astrocyte calcium signals and have an impact on gliotransmission and metabolic regulation. In addition, we discuss evidence pointing at astrocytes as potential important sources of endocannabinoid synthesis and release. Thus, we summarize recent findings that add further complexity and establish that the ECS is a fundamental effector of astrocyte functions in the brain. This article is part of the special issue on ‘Cannabinoids'. | |
| dc.description.sponsorship | Dissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes. | en_US |
| dc.description.sponsorship | Représentation sensorielle lors d'états psychotiques - ANR-16-CE37-0010 | en_US |
| dc.description.sponsorship | Recepteurs aux cannabinoides dans le codage visuel cortical | en_US |
| dc.description.sponsorship | Rôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité. - ANR-18-CE14-0029 | en_US |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Astrocyte-neuron communication | |
| dc.subject.en | Astrocytes | |
| dc.subject.en | Calcium | |
| dc.subject.en | Cannabinoid receptor 1 | |
| dc.subject.en | Metabolism | |
| dc.title.en | CB1R-dependent regulation of astrocyte physiology and astrocyte-neuron interactions | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.neuropharm.2021.108678 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 34157362 | en_US |
| bordeaux.journal | Neuropharmacology | en_US |
| bordeaux.volume | 195 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.institution | INSERM | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | European Research Council | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| hal.identifier | hal-03385993 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-10-19T14:37:37Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuropharmacology&rft.date=2021-09-01&rft.volume=195&rft.eissn=0028-3908&rft.issn=0028-3908&rft.au=COVELO%20FERNANDEZ,%20Ana&ERASO-PICHOT,%20Abel&FERNANDEZ-MONCADA,%20Ignacio&SERRAT,%20Roman&MARSICANO,%20Giovanni&rft.genre=article |
