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Cancer incidence in agricultural workers: Findings from an international consortium of agricultural cohort studies (AGRICOH)

dc.rights.licenseopenen_US
dc.contributor.authorTOGAWA, Kayo
dc.contributor.authorLEON, Maria E.
dc.contributor.authorLEBAILLY, Pierre
dc.contributor.authorBEANE FREEMAN, Laura E.
dc.contributor.authorNORDBY, Karl-Christian
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALDI, Isabelle
dc.contributor.authorMACFARLANE, Ewan
dc.contributor.authorSHIN, Aesun
dc.contributor.authorPARK, Sue
dc.contributor.authorGREENLEE, Robert T.
dc.contributor.authorSIGSGAARD, Torben
dc.contributor.authorBASINAS, Ioannis
dc.contributor.authorHOFMANN, Jonathan N.
dc.contributor.authorKJAERHEIM, Kristina
dc.contributor.authorDOUWES, Jeroen
dc.contributor.authorDENHOLM, Rachel
dc.contributor.authorFERRO, Gilles
dc.contributor.authorSIM, Malcolm R.
dc.contributor.authorKROMHOUT, Hans
dc.contributor.authorSCHUZ, Joachim
dc.date.accessioned2021-10-12T14:08:49Z
dc.date.available2021-10-12T14:08:49Z
dc.date.issued2021-08-27
dc.identifier.issn0160-4120en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112754
dc.description.abstractEnBACKGROUND: Agricultural work can expose workers to potentially hazardous agents including known and suspected carcinogens. This study aimed to evaluate cancer incidence in male and female agricultural workers in an international consortium, AGRICOH, relative to their respective general populations. METHODS: The analysis included eight cohorts that were linked to their respective cancer registries: France (AGRICAN: n = 128,101), the US (AHS: n = 51,165, MESA: n = 2,177), Norway (CNAP: n = 43,834), Australia (2 cohorts combined, Australian Pesticide Exposed Workers: n = 12,215 and Victorian Grain Farmers: n = 919), Republic of Korea (KMCC: n = 8,432), and Denmark (SUS: n = 1,899). For various cancer sites and all cancers combined, standardized incidence ratios (SIR) and 95% confidence intervals (CIs) were calculated for each cohort using national or regional rates as reference rates and were combined by random-effects meta-analysis. RESULTS: During nearly 2,800,000 person-years, a total of 23,188 cancers were observed. Elevated risks were observed for melanoma of the skin (number of cohorts = 3, meta-SIR = 1.18, CI: 1.01-1.38) and multiple myeloma (n = 4, meta-SIR = 1.27, CI: 1.04-1.54) in women and prostate cancer (n = 6, meta-SIR = 1.06, CI: 1.01-1.12), compared to the general population. In contrast, a deficit was observed for the incidence of several cancers, including cancers of the bladder, breast (female), colorectum, esophagus, larynx, lung, and pancreas and all cancers combined (n = 7, meta-SIR for all cancers combined = 0.83, 95% CI: 0.77-0.90). The direction of risk was largely consistent across cohorts although we observed large between-cohort variations in SIR for cancers of the liver and lung in men and women, and stomach, colorectum, and skin in men. CONCLUSION: The results suggest that agricultural workers have a lower risk of various cancers and an elevated risk of prostate cancer, multiple myeloma (female), and melanoma of skin (female) compared to the general population. Those differences and the between-cohort variations may be due to underlying differences in risk factors and warrant further investigation of agricultural exposures.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAgriculture
dc.subject.enFarmers
dc.subject.enOccupational health
dc.subject.enCohort
dc.subject.enConsortium
dc.subject.enCancer incidence
dc.title.enCancer incidence in agricultural workers: Findings from an international consortium of agricultural cohort studies (AGRICOH)
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.envint.2021.106825en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34461377en_US
bordeaux.journalEnvironment Internationalen_US
bordeaux.page106825en_US
bordeaux.volume157en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENEen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDNational Cancer Instituteen_US
bordeaux.identifier.funderIDLigue Contre le Canceren_US
bordeaux.identifier.funderIDMutualité Sociale Agricoleen_US
bordeaux.identifier.funderIDAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travailen_US
bordeaux.identifier.funderIDOffice National de l’Eau et des Milieux Aquatiquesen_US
bordeaux.identifier.funderIDMinistère de l'Enseignement supérieur, de la Recherche et de l'Innovationen_US
hal.identifierhal-03375258
hal.version1
hal.date.transferred2021-10-12T14:08:56Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environment%20International&rft.date=2021-08-27&rft.volume=157&rft.spage=106825&rft.epage=106825&rft.eissn=0160-4120&rft.issn=0160-4120&rft.au=TOGAWA,%20Kayo&LEON,%20Maria%20E.&LEBAILLY,%20Pierre&BEANE%20FREEMAN,%20Laura%20E.&NORDBY,%20Karl-Christian&rft.genre=article


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