Cotrimoxazole versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in HIV-infected pregnant women in Bangui, Central African Republic: a Pragmatic Randomized Controlled Trial
| dc.rights.license | open | en_US |
| dc.contributor.author | MANIRAKIZA, Alexandre | |
| dc.contributor.author | TONDEUR, Laura | |
| dc.contributor.author | YVETTE BATOUMBOU KETTA, Marie | |
| dc.contributor.author | SEPOU, Abdoulaye | |
| dc.contributor.author | SERDOUMA, Eugene | |
| dc.contributor.author | GONDJE, Samuel | |
| dc.contributor.author | GERAUD BANTHAS BATA, Ghislain | |
| dc.contributor.author | BOULAY, Aude | |
| dc.contributor.author | METHODE MOYEN, Jean | |
| dc.contributor.author | SAKANGA, Olga | |
| dc.contributor.author | LE-FOULER, Lenaig | |
| dc.contributor.author | KAZANJI, Mirdad | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BRIAND, Valerie | |
| dc.contributor.author | PIERRE LOMBART, Jean | |
| dc.contributor.author | VRAY, Muriel | |
| dc.date.accessioned | 2021-10-11T10:08:47Z | |
| dc.date.available | 2021-10-11T10:08:47Z | |
| dc.date.issued | 2021-08-18 | |
| dc.identifier.issn | 1360-2276 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112717 | |
| dc.description.abstractEn | OBJECTIVE: The main objective of the MACOMBA (Maternity and Control of Malaria-HIV co-infection in Bangui) trial was to show that cotrimoxazole (CTX) is more effective than Sulphadoxine-Pyremethamine-IPTp (IPTp-SP) to prevent placental malaria infection (primary endpoint) among HIV-positive pregnant women with a CD4+ count ≥350 cells/mm(3) in Bangui, CAR. METHODS: MACOMBA is a multicenter, open-label randomized trial conducted in four maternity hospitals in Bangui. Between 2013 and 2017, 193 women were randomized and 112 (59 and 53 in CTX and IPTp-SP arms, respectively) were assessed for placental infection defined by microscopic parasitemia or PCR. RESULTS: Thirteen women had a placental infection: 5 in the CTX arm (1 by microscopic placental parasitemia and 4 by PCR) and 8 by PCR in the SP-IPTp (8.5% vs 15.1%, p = 0.28). The percentage of newborns with low birthweight (< 2500 g) did not differ statistically between the two arms. Self-reported compliance to CTX prophylaxis was good. There was a low overall rate of adverse events in both arms. CONCLUSION: Although our results do not allow us to conclude that CTX is more effective, drug safety and good compliance among women with this treatment favour its widespread use among HIV-infected pregnant women, as currently recommended by WHO. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Malaria | |
| dc.subject.en | Pregnant women | |
| dc.subject.en | Prophylaxis HIV | |
| dc.title.en | Cotrimoxazole versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in HIV-infected pregnant women in Bangui, Central African Republic: a Pragmatic Randomized Controlled Trial | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/tmi.13668 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34407273 | en_US |
| bordeaux.journal | Tropical Medicine and International Health | en_US |
| bordeaux.page | 1314-1323 | en_US |
| bordeaux.volume | 26 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 10 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | IDLIC | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03373065 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-10-11T10:08:51Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Tropical%20Medicine%20and%20International%20Health&rft.date=2021-08-18&rft.volume=26&rft.issue=10&rft.spage=1314-1323&rft.epage=1314-1323&rft.eissn=1360-2276&rft.issn=1360-2276&rft.au=MANIRAKIZA,%20Alexandre&TONDEUR,%20Laura&YVETTE%20BATOUMBOU%20KETTA,%20Marie&SEPOU,%20Abdoulaye&SERDOUMA,%20Eugene&rft.genre=article |
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