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Platelet function and microparticle levels in atrial fibrillation: Changes during the acute episode

hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorPOURTAU, Line
hal.structure.identifierService de Cardiologie [CHRU Nancy]
dc.contributor.authorSELLAL, Jean Marc
hal.structure.identifierPhysiopathologie de l'Endothelium
hal.structure.identifierVascular research center of Marseille [VRCM]
dc.contributor.authorLACROIX, Romaric
hal.structure.identifierBIOCYTEX
dc.contributor.authorPONCELET, Philippe
hal.structure.identifierIHU-LIRYC
dc.contributor.authorBERNUS, Olivier
dc.contributor.authorCLOFENT-SANCHEZ, Gisèle
hal.structure.identifierIHU-LIRYC
dc.contributor.authorHOCINI, Mélèze
hal.structure.identifierHôpital Haut-Lévêque
dc.contributor.authorHAÏSSAGUERRE, Michel
hal.structure.identifierVascular research center of Marseille [VRCM]
dc.contributor.authorDIGNAT-GEORGE, Francoise
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorSACHER, Frédéric
hal.structure.identifierHôpital Xavier Arnozan
dc.contributor.authorNURDEN, Paquita
dc.date.accessioned2021-10-07T16:30:20Z
dc.date.available2021-10-07T16:30:20Z
dc.date.issued2017
dc.identifier.issn0167-5273
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112688
dc.description.abstractEnBackground: Thrombotic risk constitutes a major complication of atrial fibrillation (AF). Platelets and microparti-cles (MPs) are important for hemostasis and thrombosis, however their participation during AF is not well known. The aim of this study was to characterize platelet function and MPs procoagulant and fibrinolytic activity in AF patients and to determine the effects of an acute-AF episode. Methods: Blood was collected from paroxysmal (21) and persistent (16) AF patients referred for AF catheter ab-lation. Ten patients in sinus rhythm for 10 days were induced in AF allowing comparisons of left atrium samples before and after induction. Platelet aggregation with ADP, TRAP, collagen, and ristocetin was studied. Platelet surface expression of PAR-1, αIIbβ3, GPIb and P-selectin were evaluated by flow cytometry, and MPs-associated procoagulant and fibrinolytic activity levels were determined by functional assays. Results: A specific reduction in platelet aggregation to TRAP, activating the thrombin receptor PAR-1, was found in all AF patients. No differences in platelet receptor expression were found. Yet, after acute-induced AF, the platelet response was improved. Furthermore, a significant decrease of left atrium tissue factor-dependent procoagulant activity of MPs was observed. Conclusion: Acute episodes of AF results in a decrease in MPs-associated tissue factor activity, possibly corresponding to consumption, which in turn favors coagulation and the local production of thrombin. A decreased platelet basal aggregation to TRAP may result from PAR1 desensitization, whereas the improved response after an induced episode of AF suggests activation of coagulation and PAR1 re-sensitization.
dc.language.isoen
dc.publisherElsevier
dc.subject.enMicroparticles fibrinolytic activity
dc.subject.enAtrial fibrillation
dc.subject.enPlatelets
dc.subject.enThrombin receptor
dc.subject.enTissue factor
dc.subject.enMicroparticle procoagulant activity
dc.title.enPlatelet function and microparticle levels in atrial fibrillation: Changes during the acute episode
dc.typeArticle de revue
dc.identifier.doi10.1016/j.ijcard.2017.03.068
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.journalInternational Journal of Cardiology
bordeaux.page216-222
bordeaux.volume243
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01770208
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01770208v1
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