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Bidirectional modulation of hippocampal and amygdala synaptic plasticity by post-weaning obesogenic diet intake in male rats: Influence of the duration of diet exposure

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorVOUIMBA-SIGUELNITZKY, Rose-Marie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBAKOGIANNIS, Ioannis
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDUCOURNEAU, Eva Gunnel
dc.contributor.authorMAROUN, Mouna
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
dc.date.accessioned2021-09-27T13:18:36Z
dc.date.available2021-09-27T13:18:36Z
dc.date.issued2021-02
dc.identifier.issn1050-9631en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112420
dc.description.abstractEnObesity is a chronic condition associated with adverse memory and emotional outcomes in humans and animal models. We have recently demonstrated that post-weaning (i.e., periadolescent) high-fat diet (HFD)-induced obesity has opposite effect on hippocampal and amygdala-dependent memory in rodents: while HFD consumption impairs spatial and relational memory, it enhances cue-dependent emotional memory. However, it is still not clear whether this bidirectional HFD effect on memory is related to bidirectional alterations of hippocampal and amygdala synaptic plasticity and if it is influenced by the duration of diet intake. In the current study, we compared in male rats the impact of 2-3 and 6-7 months of HFD intake starting at weaning, thus covering adolescence, on in vivo long-term potentiation (LTP) recorded simultaneously in the hippocampal area CA1 and the basolateral amygdala (BLA). As expected, 6-7 months of HFD intake abolished LTP in the CA1 and enhanced LTP in the BLA. However, 2-3 months of of HFD exposure enhanced LTP in both CA1 and BLA suggesting a transient compensatory mechanism in hippocampus. These results indicate that post-weaning HFD intake progressively leads to bidirectional modulation of hippocampal and amygdala synaptic plasticity, as we previously demonstrated for related memory processes, yet with a different temporal dynamic.
dc.language.isoENen_US
dc.subject.enAdolescence
dc.subject.enAmygdala
dc.subject.enHippocampus
dc.subject.enLTP
dc.subject.enMemory
dc.subject.enObesogenic diet
dc.title.enBidirectional modulation of hippocampal and amygdala synaptic plasticity by post-weaning obesogenic diet intake in male rats: Influence of the duration of diet exposure
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/hipo.23278en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33146458en_US
bordeaux.journalHippocampusen_US
bordeaux.page117-121en_US
bordeaux.volume31en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Hippocampus&rft.date=2021-02&rft.volume=31&rft.issue=2&rft.spage=117-121&rft.epage=117-121&rft.eissn=1050-9631&rft.issn=1050-9631&rft.au=VOUIMBA-SIGUELNITZKY,%20Rose-Marie&BAKOGIANNIS,%20Ioannis&DUCOURNEAU,%20Eva%20Gunnel&MAROUN,%20Mouna&FERREIRA,%20Guillaume&rft.genre=article


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