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Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice

dc.rights.licenseopenen_US
dc.contributor.authorDEMERS, Genevieve
dc.contributor.authorROY, Jerome
dc.contributor.authorMACHUCA-PARRA, Arturo Israel
dc.contributor.authorDASHTEHEI POUR, Zahra
dc.contributor.authorBAIRAMIAN, Diane
dc.contributor.authorDANEAULT, Caroline
dc.contributor.authorROSIERS, Christine Des
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
dc.contributor.authorALQUIER, Thierry
dc.contributor.authorFULTON, Stephanie
dc.date.accessioned2021-09-27T13:10:39Z
dc.date.available2021-09-27T13:10:39Z
dc.date.issued2020
dc.identifier.issn0307-0565en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112419
dc.description.abstractEnObjective: Obesity significantly elevates the odds of developing mood disorders. Chronic consumption of a saturated high-fat diet (HFD) elicits anxiodepressive behavior in a manner linked to metabolic dysfunction and neuroinflammation in mice. Dietary omega-3 polyunsaturated fatty acids (n-3 PUFA) can improve both metabolic and mood impairments by relieving inflammation. Despite these findings, the effects of n-3 PUFA supplementation on energy homeostasis, anxiodepressive behavior, brain lipid composition, and gliosis in the diet-induced obese state are unclear. Methods: Male C57Bl/6J mice were fed a saturated high-fat diet (HFD) or chow for 20 weeks. During the last 5 weeks mice received daily gavage (“supplementation”) of fish oil (FO) enriched with equal amounts of docosahexaenoic (DHA) and eicosapentaenoic acid (EPA) or control corn oil. Food intake and body weight were measured throughout while additional metabolic parameters and anxiety- and despair-like behavior (elevated-plus maze, light–dark box, and forced swim tasks) were evaluated during the final week of supplementation. Forebrain lipid composition and markers of microglia activation and astrogliosis were assessed by gas chromatography–mass spectrometry and real-time PCR, respectively. Results: Five weeks of FO supplementation corrected glucose intolerance and attenuated hyperphagia in HFD-induced obese mice without affecting adipose mass. FO supplementation also defended against the anxiogenic and depressive-like effects of HFD. Brain lipids, particularly anti-inflammatory PUFA, were diminished by HFD, whereas FO restored levels beyond control values. Gene expression markers of brain reactive gliosis were supressed by FO. Conclusions: Supplementing a saturated HFD with FO rich in EPA and DHA corrects glucose intolerance, inhibits food intake, suppresses anxiodepressive behaviors, enhances anti-inflammatory brain lipids, and dampens indices of brain gliosis in obese mice. Together, these findings support increasing dietary n-3 PUFA for the treatment of metabolic and mood disturbances associated with excess fat intake and obesity.
dc.language.isoENen_US
dc.title.enFish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41366-020-0623-6en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32546855en_US
bordeaux.journalInternational Journal of Obesityen_US
bordeaux.page1936-1945en_US
bordeaux.volume44en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Obesity&rft.date=2020&rft.volume=44&rft.spage=1936-1945&rft.epage=1936-1945&rft.eissn=0307-0565&rft.issn=0307-0565&rft.au=DEMERS,%20Genevieve&ROY,%20Jerome&MACHUCA-PARRA,%20Arturo%20Israel&DASHTEHEI%20POUR,%20Zahra&BAIRAMIAN,%20Diane&rft.genre=article


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