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Insular and Ventrolateral Orbitofrontal Cortices Differentially Contribute to Goal-Directed Behavior in Rodents

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorPARKES, Shauna
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorRAVASSARD, Pascal
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCERPA, Juan-Carlos
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorWOLFF, Mathieu
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCOUTUREAU, Etienne
dc.date.accessioned2021-09-27T12:24:05Z
dc.date.available2021-09-27T12:24:05Z
dc.date.issued2018-07
dc.identifier.issn1047-3211en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112413
dc.description.abstractEnThe medial prefrontal cortex (mPFC) has long been considered a critical site in action control. However, recent evidence indicates that the contribution of cortical areas to goal-directed behavior likely extends beyond mPFC. Here, we examine the function of both insular (IC) and ventrolateral orbitofrontal (vlOFC) cortices in action-dependent learning. We used chemogenetics to study the consequences of IC or vlOFC inhibition on acquisition and performance of instrumental actions using the outcome devaluation task. Rats first learned to associate actions with desirable outcomes. Then, one of these outcomes was devalued and we assessed the rats' choice between the 2 actions. Typically, rats will bias their selection towards the action that delivers the still valued outcome. We show that chemogenetic-induced inhibition of IC during choice abolishes goal-directed control whereas inhibition during instrumental acquisition is without effect. IC is therefore necessary for action selection based on current outcome value. By contrast, vlOFC inhibition during acquisition or the choice test impaired goal-directed behavior but only following a shift in the instrumental contingencies. Our results provide clear evidence that vlOFC plays a critical role in action-dependent learning, which challenges the popular idea that this region of OFC is exclusively involved in stimulus-dependent behaviors.
dc.description.sponsorshipBases neuronales du comportement dirigé vers un but chez le Rat - ANR-14-CE13-0014en_US
dc.language.isoENen_US
dc.subject.enAction
dc.subject.enDREADD
dc.subject.enInstrumental conditioning
dc.subject.enOutcome devaluation
dc.subject.enReversal
dc.title.enInsular and Ventrolateral Orbitofrontal Cortices Differentially Contribute to Goal-Directed Behavior in Rodents
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cercor/bhx132en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed28541407en_US
dc.description.sponsorshipEuropeInternational Mobility Programme to Strengthen Skills and Excellence in Research for Agricultureen_US
bordeaux.journalCerebral Cortexen_US
bordeaux.page2313-2325en_US
bordeaux.volume28en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDAgreenSkillsen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral%20Cortex&rft.date=2018-07&rft.volume=28&rft.issue=7&rft.spage=2313-2325&rft.epage=2313-2325&rft.eissn=1047-3211&rft.issn=1047-3211&rft.au=PARKES,%20Shauna&RAVASSARD,%20Pascal&CERPA,%20Juan-Carlos&WOLFF,%20Mathieu&FERREIRA,%20Guillaume&rft.genre=article


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