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dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJANTHAKHIN, Yootana
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorRINCEL, Marion
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCOSTA, Anna-Maria
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDARNAUDERY, Muriel
IDREF: 124892264
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
dc.date.accessioned2021-09-27T12:19:11Z
dc.date.available2021-09-27T12:19:11Z
dc.date.issued2017
dc.identifier.issn0306-4530en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112412
dc.description.abstractEnEarly-life exposure to calorie-dense food, rich in fat and sugar, contributes to the increasing prevalence of obesity and its associated adverse cognitive and emotional outcomes at adulthood. It is thus critical to determine the impact of such nutritional environment on neurobehavioral development. In animals, maternal high-fat diet (HFD) consumption impairs hippocampal function in adult offspring, but its impact on hippocampal neuronal morphology is unknown. Moreover, the consequences of perinatal HFD exposure on the amygdala, another important structure for emotional and cognitive processes, remain to be established. In rats, we show that adult offspring from dams fed with HFD (45% from fat, throughout gestation and lactation) exhibit atrophy of pyramidal neuron dendrites in both the CA1 of the hippocampus and the basolateral amygdala (BLA). Perinatal HFD exposure also impairs conditioned odor aversion, a task highly dependent on BLA function, without affecting olfactory or malaise processing. Neuronal morphology and behavioral alterations elicited by perinatal HFD are not associated with body weight changes but with higher plasma leptin levels at postnatal day 15 and at adulthood. Taken together, our results suggest that perinatal HFD exposure alters hippocampal and amygdala neuronal morphology which could participate to memory alterations at adulthood.
dc.language.isoENen_US
dc.subject.enMaternal diet
dc.subject.enDendritic length
dc.subject.enSpine density
dc.subject.enGolgi-Cox
dc.subject.enMemory
dc.subject.enRat
dc.subject.enObesity
dc.subject.enRemembering
dc.title.enMaternal high-fat diet leads to hippocampal and amygdala dendritic remodeling in adult male offspring
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.psyneuen.2017.05.003en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed28595087en_US
bordeaux.journalPsychoneuroendocrinologyen_US
bordeaux.page49-57en_US
bordeaux.volume83en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychoneuroendocrinology&rft.date=2017&rft.volume=83&rft.spage=49-57&rft.epage=49-57&rft.eissn=0306-4530&rft.issn=0306-4530&rft.au=JANTHAKHIN,%20Yootana&RINCEL,%20Marion&COSTA,%20Anna-Maria&DARNAUDERY,%20Muriel&FERREIRA,%20Guillaume&rft.genre=article


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