Acquisition of specific response-outcome associations requires NMDA receptor activation in the basolateral amygdala but not in the insular cortex
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | PARKES, Shauna | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FERREIRA, Guillaume | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | COUTUREAU, Etienne | |
| dc.date.accessioned | 2021-09-27T10:22:08Z | |
| dc.date.available | 2021-09-27T10:22:08Z | |
| dc.date.issued | 2016-02 | |
| dc.identifier.issn | 1074-7427 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112407 | |
| dc.description.abstractEn | The basolateral amygdala (BLA) and the gustatory region of the insular cortex (IC) are required for the encoding and retrieval of outcome value. Here, we examined if these regions are also necessary to learn associations between actions and their outcomes. Hungry rats were first trained to press two levers for a common outcome. Next, specific response-outcome (R-O) associations were introduced such that each response now earned a distinct food outcome. Prior to each specific R-O training session, rats received a bilateral infusion of the N-methyl-d-aspartate (NMDA) receptor antagonist, DL-APV, into either the BLA or the IC. One of the two outcomes was then devalued immediately prior to a choice test. Inhibition of NMDA receptor activity in the BLA, but not the IC, during the acquisition of specific R-O associations abolished selective devaluation. These results indicate that the BLA is critical for learning the association between actions and their specific consequences. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Goal-directed behavior | |
| dc.subject.en | Instrumental | |
| dc.subject.en | Conditioning | |
| dc.subject.en | Acquisition | |
| dc.subject.en | Amygdala | |
| dc.subject.en | Insular cortex | |
| dc.title.en | Acquisition of specific response-outcome associations requires NMDA receptor activation in the basolateral amygdala but not in the insular cortex | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.nlm.2015.12.005 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 26740161 | en_US |
| bordeaux.journal | Neurobiology of Learning and Memory | en_US |
| bordeaux.page | 40-45 | en_US |
| bordeaux.volume | 128 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neurobiology%20of%20Learning%20and%20Memory&rft.date=2016-02&rft.volume=128&rft.spage=40-45&rft.epage=40-45&rft.eissn=1074-7427&rft.issn=1074-7427&rft.au=PARKES,%20Shauna&FERREIRA,%20Guillaume&COUTUREAU,%20Etienne&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||