Acquisition of specific response-outcome associations requires NMDA receptor activation in the basolateral amygdala but not in the insular cortex
PARKES, Shauna
Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
Nutrition et Neurobiologie intégrée [NutriNeuro]
Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
Nutrition et Neurobiologie intégrée [NutriNeuro]
PARKES, Shauna
Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
Nutrition et Neurobiologie intégrée [NutriNeuro]
< Leer menos
Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
Nutrition et Neurobiologie intégrée [NutriNeuro]
Idioma
EN
Article de revue
Este ítem está publicado en
Neurobiology of Learning and Memory. 2016-02, vol. 128, p. 40-45
Resumen en inglés
The basolateral amygdala (BLA) and the gustatory region of the insular cortex (IC) are required for the encoding and retrieval of outcome value. Here, we examined if these regions are also necessary to learn associations ...Leer más >
The basolateral amygdala (BLA) and the gustatory region of the insular cortex (IC) are required for the encoding and retrieval of outcome value. Here, we examined if these regions are also necessary to learn associations between actions and their outcomes. Hungry rats were first trained to press two levers for a common outcome. Next, specific response-outcome (R-O) associations were introduced such that each response now earned a distinct food outcome. Prior to each specific R-O training session, rats received a bilateral infusion of the N-methyl-d-aspartate (NMDA) receptor antagonist, DL-APV, into either the BLA or the IC. One of the two outcomes was then devalued immediately prior to a choice test. Inhibition of NMDA receptor activity in the BLA, but not the IC, during the acquisition of specific R-O associations abolished selective devaluation. These results indicate that the BLA is critical for learning the association between actions and their specific consequences.< Leer menos
Palabras clave en inglés
Goal-directed behavior
Instrumental
Conditioning
Acquisition
Amygdala
Insular cortex
Centros de investigación