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Maternal high-fat diet prevents developmental programming by early life stress

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDARNAUDERY, Muriel
IDREF: 124892264
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorRINCEL, Marion
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLEPINAY, Amandine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDELAGE, Pauline
dc.contributor.authorTHEODOROU, Vassilia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
dc.date.accessioned2021-09-24T12:14:23Z
dc.date.available2021-09-24T12:14:23Z
dc.date.issued2016
dc.identifier.issn0306-4530en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112379
dc.description.abstractEnBackground: Anxiety disorders and depression are well documented in subjects exposed to adverse childhood events. Recently, maternal obesity and maternal consumption of high-fat diets (HFD) have been also proposed as risk factors for offspring mental health. Here, using an animal model in rats, we explored the combinatorial effects of perinatal exposure to HFD and stress in offspring. Methods: Dams were exposed to HFD throughout gestation and lactation and maternal separation (MS) was used to mimic early psychosocial stress. Results: In the prefrontal cortex (PFC) of pups, MS led to changes in the expression of several genes such as Bdnf (brain derived neurotrophic factor), 5HT-r1a (serotonin receptor 1a) and Rest4 (neuron-restrictive silencer element, repressor element 1, silencing transcription factor (Rest), splicing variant 4). Contrary to our hypothesis, perinatal HFD strongly attenuated the developmental alterations induced by MS. Furthermore, maternal HFD totally prevented the endophenotypes associated with MS in adulthood. Notably, perinatal HFD per se had no impact in the offspring. Finally, we show that HFD intake reduced anxiety and enhanced maternal care in stressed dams. Conclusions: Our results reveal a protective effect of fat on the immature brain in a context of early life stress, possibly through an anti-stress effect in dams.
dc.language.isoENen_US
dc.title.enMaternal high-fat diet prevents developmental programming by early life stress
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.psyneuen.2016.07.165en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.journalPsychoneuroendocrinologyen_US
bordeaux.page64en_US
bordeaux.volume71en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issueSupplémenten_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychoneuroendocrinology&rft.date=2016&rft.volume=71&rft.issue=Suppl%C3%A9ment&rft.spage=64&rft.epage=64&rft.eissn=0306-4530&rft.issn=0306-4530&rft.au=DARNAUDERY,%20Muriel&RINCEL,%20Marion&LEPINAY,%20Amandine&DELAGE,%20Pauline&THEODOROU,%20Vassilia&rft.genre=article


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