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POMC neurons dysfunction in diet-induced metabolic disease: hallmark or mechanism of disease?

dc.rights.licenseopenen_US
dc.contributor.authorQUARTA, Carmelo
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFIORAMONTI, Xavier
dc.contributor.authorCOTA, Daniela
dc.date.accessioned2021-09-24T07:46:01Z
dc.date.available2021-09-24T07:46:01Z
dc.date.issued2020-11-01
dc.identifier.issn0306-4522en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112364
dc.description.abstractEnOne important lesson from the last decade of studies in the field of systemic energy metabolism is that obesity is first and foremost a brain disease. Hypothalamic neurons dysfunction observed in response to chronic metabolic stress is a key pathogenic node linking consumption of hypercaloric diets with body weight gain and associated metabolic sequelae. A key hypothalamic neuronal population expressing the neuropeptide Pro-opio-melanocortin (POMC) displays altered electrical activity and dysregulated neuropeptides production capacity after long-term feeding with hypercaloric diets. However, whether such neuronal dysfunction represents a consequence or a mechanism of disease, remains a subject of debate. Here, we will review and highlight emerging pathogenic mechanisms that explain why POMC neurons undergo dysfunctional activity in response to caloric overload, and critically address whether these mechanisms may be causally implicated in the physiopathology of obesity and of its associated co-morbidities.
dc.description.sponsorshipInnovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeur - ANR-10-EQPX-0008en_US
dc.description.sponsorshipLa signalisation des acides biliaires dans le cerveau et son rôle dans le contrôle métabolique - ANR-17-CE14-0007en_US
dc.description.sponsorshipRôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité. - ANR-18-CE14-0029en_US
dc.language.isoENen_US
dc.subject.enHypothalamus
dc.subject.enObesity
dc.subject.enDiet
dc.subject.enPOMC neurons
dc.subject.enElectrical activity
dc.title.enPOMC neurons dysfunction in diet-induced metabolic disease: hallmark or mechanism of disease?
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neuroscience.2019.09.031en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed31689486en_US
bordeaux.journalNeuroscienceen_US
bordeaux.page3-14en_US
bordeaux.volume447en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDSociété Française d’Endocrinologieen_US
bordeaux.identifier.funderIDSociété Française de Nutritionen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDLabEx BRAINen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuroscience&rft.date=2020-11-01&rft.volume=447&rft.spage=3-14&rft.epage=3-14&rft.eissn=0306-4522&rft.issn=0306-4522&rft.au=QUARTA,%20Carmelo&FIORAMONTI,%20Xavier&COTA,%20Daniela&rft.genre=article


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