POMC neurons dysfunction in diet-induced metabolic disease: hallmark or mechanism of disease?
dc.rights.license | open | en_US |
dc.contributor.author | QUARTA, Carmelo | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | FIORAMONTI, Xavier | |
dc.contributor.author | COTA, Daniela | |
dc.date.accessioned | 2021-09-24T07:46:01Z | |
dc.date.available | 2021-09-24T07:46:01Z | |
dc.date.issued | 2020-11-01 | |
dc.identifier.issn | 0306-4522 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112364 | |
dc.description.abstractEn | One important lesson from the last decade of studies in the field of systemic energy metabolism is that obesity is first and foremost a brain disease. Hypothalamic neurons dysfunction observed in response to chronic metabolic stress is a key pathogenic node linking consumption of hypercaloric diets with body weight gain and associated metabolic sequelae. A key hypothalamic neuronal population expressing the neuropeptide Pro-opio-melanocortin (POMC) displays altered electrical activity and dysregulated neuropeptides production capacity after long-term feeding with hypercaloric diets. However, whether such neuronal dysfunction represents a consequence or a mechanism of disease, remains a subject of debate. Here, we will review and highlight emerging pathogenic mechanisms that explain why POMC neurons undergo dysfunctional activity in response to caloric overload, and critically address whether these mechanisms may be causally implicated in the physiopathology of obesity and of its associated co-morbidities. | |
dc.description.sponsorship | Innovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeur - ANR-10-EQPX-0008 | en_US |
dc.description.sponsorship | La signalisation des acides biliaires dans le cerveau et son rôle dans le contrôle métabolique - ANR-17-CE14-0007 | en_US |
dc.description.sponsorship | Rôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité. - ANR-18-CE14-0029 | en_US |
dc.language.iso | EN | en_US |
dc.subject.en | Hypothalamus | |
dc.subject.en | Obesity | |
dc.subject.en | Diet | |
dc.subject.en | POMC neurons | |
dc.subject.en | Electrical activity | |
dc.title.en | POMC neurons dysfunction in diet-induced metabolic disease: hallmark or mechanism of disease? | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.neuroscience.2019.09.031 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 31689486 | en_US |
bordeaux.journal | Neuroscience | en_US |
bordeaux.page | 3-14 | en_US |
bordeaux.volume | 447 | en_US |
bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INRAE | en_US |
bordeaux.institution | INSERM | |
bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
bordeaux.identifier.funderID | Société Française d’Endocrinologie | en_US |
bordeaux.identifier.funderID | Société Française de Nutrition | en_US |
bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
bordeaux.identifier.funderID | LabEx BRAIN | en_US |
bordeaux.identifier.funderID | Institut National de la Recherche Agronomique | en_US |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuroscience&rft.date=2020-11-01&rft.volume=447&rft.spage=3-14&rft.epage=3-14&rft.eissn=0306-4522&rft.issn=0306-4522&rft.au=QUARTA,%20Carmelo&FIORAMONTI,%20Xavier&COTA,%20Daniela&rft.genre=article |
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