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Maternal high-fat diet prevents developmental programming by early-life stress

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorRINCEL, Marion
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLEPINAY, Amandine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDELAGE, Pierre
dc.contributor.authorFIORAMONTI, Jean
dc.contributor.authorTHEODOROU, Vassilia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDARNAUDERY, Muriel
IDREF: 124892264
dc.date.accessioned2021-09-24T07:05:44Z
dc.date.available2021-09-24T07:05:44Z
dc.date.issued2016-11-29
dc.identifier.issn2158-3188en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112355
dc.description.abstractEnAnxiety disorders and depression are well-documented in subjects exposed to adverse childhood events. Recently, maternal obesity and/or maternal consumption of high-fat diets (HFD) have been also proposed as risk factors for offspring mental health. Here using an animal model in rats, we explored the combinatorial effects of a maternal HFD (40% of energy from fat without impact on maternal weight; during gestation and lactation) and maternal separation (MS) in offspring. In the prefrontal cortex (PFC) of pups, MS led to changes in the expression of several genes such as Bdnf (brain derived neurotrophic factor), 5HT-r1a (serotonin receptor 1a) and Rest4 (neuron-restrictive silencer element, repressor element 1, silencing transcription factor (Rest), splicing variant 4). Surprisingly, perinatal HFD strongly attenuated the developmental alterations induced by MS. Furthermore, maternal HFD totally prevented the endophenotypes (anxiety, spatial memory, social behavior, hypothalamic–pituitary–adrenal (HPA) axis response to stress, hippocampal neurogenesis and visceral pain) associated with MS at adulthood. Finally, we also demonstrated that HFD intake reduced anxiety and enhanced maternal care in stressed dams. Overall, our data suggest that a HFD restricted to gestation and lactation, which did not lead to overweight in dams, had limited effects in unstressed offspring, highlighting the role of maternal obesity, rather than fat exposure per se, on brain vulnerability during development.
dc.description.sponsorshipEnvironnement psychosocial précoce, empreintes biologiques et épigénétiques et état de santé à l'âge adulte - ANR-12-DSSA-0004en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectSanté humaine
dc.subjectCerveau
dc.subjectComportement maternel
dc.subjectCritère de stress
dc.subjectGrossesse
dc.subjectRégime alimentaire
dc.subjectSystème nerveux central
dc.subject.enHuman health
dc.subject.enCentral nervous system
dc.subject.enMothering ability
dc.subject.enPregnancy
dc.subject.enRat
dc.title.enMaternal high-fat diet prevents developmental programming by early-life stress
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/tp.2016.235en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed27898075en_US
bordeaux.journalTranslational Psychiatryen_US
bordeaux.pagee966en_US
bordeaux.volume6en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDDepartement Alimentation Humaine, Institut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDMinistère de l'Enseignement supérieur, de la Recherche et de l'Innovationen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational%20Psychiatry&rft.date=2016-11-29&rft.volume=6&rft.issue=11&rft.spage=e966&rft.epage=e966&rft.eissn=2158-3188&rft.issn=2158-3188&rft.au=RINCEL,%20Marion&LEPINAY,%20Amandine&DELAGE,%20Pierre&FIORAMONTI,%20Jean&THEODOROU,%20Vassilia&rft.genre=article


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