Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | RINCEL, Marion | |
| dc.contributor.author | OLIER, Maiwenn | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MINNI, Amandine | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MONCHAUX DE OLIVEIRA, Camille | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MATIME, Yann | |
| dc.contributor.author | GAULTIER, Eric | |
| dc.contributor.author | GRIT, Isabelle I. | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | HELBLING, Jean Christophe | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | COSTA, Anna-Maria | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LEPINAY, Amandine | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MOISAN, Marie Pierre
IDREF: 060242264 | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie | |
| dc.contributor.author | FERRIER, Laurent | |
| dc.contributor.author | PARNET, Patricia | |
| dc.contributor.author | THEODOROU, Vassilia | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DARNAUDERY, Muriel | |
| dc.date.accessioned | 2021-09-22T15:10:36Z | |
| dc.date.available | 2021-09-22T15:10:36Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 0033-3158 (Print) 1432-2072 (Online) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112341 | |
| dc.description.abstractEn | Intestinal permeability plays an important role in gut-brain axis communication. Recent studies indicate that intestinal permeability increases in neonate pups during maternal separation (MS). The present study aims to determine whether pharmacological inhibition of myosin light chain kinase (MLCK), which regulates tight junction contraction and controls intestinal permeability, in stressed neonates, protects against the long-term effects of MS. Male Wistar rats were exposed to MS (3 h per day from post-natal day (PND)2 to PND14) or left undisturbed and received daily intraperitoneal injection of a MLCK inhibitor (ML-7, 5 mg/kg) or vehicle during the same period. At adulthood, emotional behaviors, corticosterone response to stress, and gut microbiota composition were analyzed. ML-7 restored gut barrier function in MS rats specifically during the neonatal period. Remarkably, ML-7 prevented MS-induced sexual reward-seeking impairment and reversed the alteration of corticosterone response to stress at adulthood. The effects of ML-7 were accompanied by the normalization of the abundance of members of Lachnospiraceae, Clostridiales, Desulfovibrio, Bacteroidales, Enterorhabdus, and Bifidobacterium in the feces of MS rats at adulthood. Altogether, our work suggests that improvement of intestinal barrier defects during development may alleviate some of the long-term effects of early-life stress and provides new insight on brain-gut axis communication in a context of stress. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | 16S sequencing | |
| dc.subject.en | Animal models | |
| dc.subject.en | Blood-brain barrier | |
| dc.subject.en | Depression | |
| dc.subject.en | Early-life stress | |
| dc.subject.en | Female urine sniffing test | |
| dc.subject.en | Intestinal barrier | |
| dc.subject.en | Intestinal permeability | |
| dc.subject.en | Irritable bowel syndrome | |
| dc.subject.en | Myosin light chain kinase | |
| dc.title.en | Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s00213-019-05252-w | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| bordeaux.journal | Psychopharmacology | en_US |
| bordeaux.page | 1583-1596 | en_US |
| bordeaux.volume | 236 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Université de Bordeaux | en_US |
| bordeaux.identifier.funderID | Departement Alimentation Humaine, Institut National de la Recherche Agronomique | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.identifier.funderID | Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychopharmacology&rft.date=2019&rft.volume=236&rft.issue=5&rft.spage=1583-1596&rft.epage=1583-1596&rft.eissn=0033-3158%20(Print)%201432-2072%20(Online)&rft.issn=0033-3158%20(Print)%201432-2072%20(Online)&rft.au=RINCEL,%20Marion&OLIER,%20Maiwenn&MINNI,%20Amandine&MONCHAUX%20DE%20OLIVEIRA,%20Camille&MATIME,%20Yann&rft.genre=article |
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