The impact of insulin on the serotonergic system and consequences on diabetes-associated mood disorders
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MARTIN, Hugo | |
| dc.contributor.author | BULLICH, Sebastien | |
| dc.contributor.author | GUIARD, Bruno | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FIORAMONTI, Xavier | |
| dc.date.accessioned | 2021-09-22T12:59:16Z | |
| dc.date.available | 2021-09-22T12:59:16Z | |
| dc.date.issued | 2021-04 | |
| dc.identifier.issn | 0953-8194 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112327 | |
| dc.description.abstractEn | The idea that insulin could influence emotional behaviours has long been suggested. However, the underlying mechanisms have yet to be solved and there is no direct and clear-cut evidence demonstrating that such action involves brain serotonergic neurones. Indeed, initial arguments in favour of the association between insulin, serotonin and mood arise from clinical or animal studies showing that impaired insulin action in type 1 or type 2 diabetes causes anxiety- and depressive symptoms along with blunted plasma and brain serotonin levels. The present review synthesises the main mechanistic hypotheses that might explain the comorbidity between diabetes and depression. It also provides a state of knowledge of the direct and indirect experimental evidence that insulin modulates brain serotonergic neurones. Finally, it highlights the literature suggesting that antidiabetic drugs present antidepressant-like effects and, conversely, that serotonergic antidepressants impact glucose homeostasis. Overall, this review provides mechanistic insights into how insulin signalling alters serotonergic neurotransmission and related behaviours bringing new targets for therapeutic options. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Antidepressant | |
| dc.subject.en | Depression | |
| dc.subject.en | Diabetes | |
| dc.subject.en | Insulin | |
| dc.subject.en | Serotonin | |
| dc.title.en | The impact of insulin on the serotonergic system and consequences on diabetes-associated mood disorders | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/jne.12928 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 33506507 | en_US |
| bordeaux.journal | Journal of Neuroendocrinology | en_US |
| bordeaux.volume | 33 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Recherche Agronomique | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Neuroendocrinology&rft.date=2021-04&rft.volume=33&rft.issue=4&rft.eissn=0953-8194&rft.issn=0953-8194&rft.au=MARTIN,%20Hugo&BULLICH,%20Sebastien&GUIARD,%20Bruno&FIORAMONTI,%20Xavier&rft.genre=article |
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