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Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLEYROLLE, Quentin
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDECOEUR, Fanny
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBRIERE, G.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAMADIEU, Camille
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorQUADROS, A.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorVOYTYUK, I.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLACABANNE, Chloe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBENMAMAR-BADEL, Anouk
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOUREL, Julien
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAUBERT, Agnes
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorSERE, Alexandra
dc.contributor.authorCHAIN, F.
dc.contributor.authorSCHWENDIMANN, Leslie
dc.contributor.authorMATROT, B.
dc.contributor.authorBOURGEOIS, T.
dc.contributor.authorGREGOIRE, Stephane
dc.contributor.authorLEBLANC, Thierry
dc.contributor.authorDE MORENO DE LEBLANC, A.
dc.contributor.authorLANGELLA, P.
dc.contributor.authorFERNANDES, G.
dc.contributor.authorBRETILLON, Lionel
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJOFFRE, Corinne
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
dc.contributor.authorURICARU, Raluca
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
dc.contributor.authorTHEBAULT, Patricia
dc.contributor.authorGRESSENS, Pierre
dc.contributor.authorCHATEL, J. M.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorNADJAR, Agnes
dc.date.accessioned2021-09-22T12:37:48Z
dc.date.available2021-09-22T12:37:48Z
dc.date.issued2021-02
dc.identifier.issn0893-133Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112325
dc.description.abstractEnMaternal immune activation (MIA) and poor maternal nutritional habits are risk factors for the occurrence of neurodevelopmental disorders (NDD). Human studies show the deleterious impact of prenatal inflammation and low n-3 polyunsaturated fatty acid (PUFA) intake on neurodevelopment with long-lasting consequences on behavior. However, the mechanisms linking maternal nutritional status to MIA are still unclear, despite their relevance to the etiology of NDD. We demonstrate here that low maternal n-3 PUFA intake worsens MIA-induced early gut dysfunction, including modification of gut microbiota composition and higher local inflammatory reactivity. These deficits correlate with alterations of microglia-neuron crosstalk pathways and have long-lasting effects, both at transcriptional and behavioral levels. This work highlights the perinatal period as a critical time window, especially regarding the role of the gut-brain axis in neurodevelopment, elucidating the link between MIA, poor nutritional habits, and NDD.
dc.language.isoENen_US
dc.title.enMaternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41386-020-00793-7en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32781459en_US
bordeaux.journalNeuropsychopharmacologyen_US
bordeaux.page579–602en_US
bordeaux.volume46en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuropsychopharmacology&rft.date=2021-02&rft.volume=46&rft.spage=579%E2%80%93602&rft.epage=579%E2%80%93602&rft.eissn=0893-133X&rft.issn=0893-133X&rft.au=LEYROLLE,%20Quentin&DECOEUR,%20Fanny&BRIERE,%20G.&AMADIEU,%20Camille&QUADROS,%20A.&rft.genre=article


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