Afficher la notice abrégée

A multi-compound extract of Rhodiola rosea reduced acute mild stress-induced corticosterone release in mice more than salidroside alone

dc.rights.licenseopenen_US
dc.contributor.authorGUINOBERT, Isabelle
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDINEL, Anne Laure
ORCID: 0000-0002-8668-9413
IDREF: 131872109
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJOFFRE, Corinne
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorPALLET, Veronique
ORCID: 0000-0002-9078-3269
IDREF: 066841763
dc.contributor.authorBARDOT, Valerie
dc.contributor.authorBERTHOMIER, Lucile
dc.contributor.authorRIPOCHE, Isabelle
dc.contributor.authorDUBOURDEAUX, M.
dc.date.accessioned2021-09-22T10:01:13Z
dc.date.available2021-09-22T10:01:13Z
dc.date.issued2019-09
dc.date.conference2019-09-01
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112317
dc.descriptionPosteren_US
dc.description.abstractEnCongress abstract : We have previously shown that a multi-component hydroethanolic root extract (HRE) of Rhodiola rosea (patented process Phytostandard®; EPS Rhodiole, PiLeJe Laboratoire) induces a decrease in corticosterone secretion and a faster return to normal plasma corticosterone levels than the vehicle in mice subjected to acute mild stress. In this study, we determined the phytochemical profile of the HRE (HPTLC, HPLC, LC-MS and MS/MS) and compared its effect to one of its active compound, salidroside. After daily gavage with the HRE (240 mg of dry material/kg) or salidroside (equivalence: 3.6 mg/kg) during 2 weeks, mice were subjected or not to acute mild stress (open-field + elevated plus-maze tests). Corticosterone was measured in plasma collected from the mandibular vein at 0, 30, 60 and 90 min after stress initiation. Salidroside, rosavin, various flavonoids, monoterpene glycosides and several phenylpropanoid derivatives were identified in the HRE. Mice supplemented with the HRE presented a dampening of corticosterone secretion compared to salidroside-fed mice at the different time points. No modulation of stress-responsive gene expression was observed in our conditions. These results highlight the advantage of extracts with a composition close to that of the plant totum (i.e. all the active compounds of the plant) compared to a single compound since mice supplemented with the HRE presented a decrease in stress reactivity in an acute mild stress situation which could be associated to a better resilience to stress.
dc.language.isoENen_US
dc.title.enA multi-compound extract of Rhodiola rosea reduced acute mild stress-induced corticosterone release in mice more than salidroside alone
dc.typeAutre communication scientifique (congrès sans actes - poster - séminaire...)en_US
dc.identifier.doi10.1055/s-0039-3399942
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.volume85en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue18en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.conference.title67. International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA)en_US
bordeaux.countryaten_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.conference.cityInnsbrucken_US
bordeaux.peerReviewedouien_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2019-09&rft.volume=85&rft.issue=18&rft.au=GUINOBERT,%20Isabelle&DINEL,%20Anne%20Laure&JOFFRE,%20Corinne&PALLET,%20Veronique&BARDOT,%20Valerie&rft.genre=conference


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée