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Chronic inflammation in hepatitis C patients is associated with increased perceived stress and abnormal connectivity between insula and basal ganglia

dc.rights.licenseopenen_US
dc.contributor.authorORIOLO, G.
dc.contributor.authorNAVINES, R.
dc.contributor.authorBLANCO, L.
dc.contributor.authorMARTIN-HERNANDEZ, D.
dc.contributor.authorMARINO, Z.
dc.contributor.authorCAVERO, M.
dc.contributor.authorSOLA, R.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
IDREF: 167018736
dc.contributor.authorLEZA, J.C.
dc.contributor.authorPUJOL, J.
dc.contributor.authorFORNS, X.
dc.contributor.authorMARTIN-SANTOS, R.
dc.date.accessioned2021-09-21T13:31:32Z
dc.date.available2021-09-21T13:31:32Z
dc.date.issued2018-10
dc.identifier.issn0924-977Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112297
dc.description.abstractEnBackground: Sickness Behavior(SB) is an organized adaptive strategy to support the organism's defense against pathogens [1]. Nevertheless,when the pathogen cannot be removed and is persistent,SB may become prolonged and dysfunctional,as in chronic hepatitis C(CHC) [2].The presence of chronic inflammation,beside vulnerability factors,seems to be crucial for the development of major depressive disorder(MDD),while impacting neuroimmune circuits or oxidative and nitrosative(O&NS) pathways [3]. Neuroimaging studies have pointed out the role of brain structures relevant to the SB,helping to identify those areas sensitive to peripheral inflammation such as basal ganglia or insula [4,5]. Aim: To elucidate clinical and neurobiological aspects of inflammation in CHC patients without current MDD diagnosis. Methods: Case-control study compared 35 CHC patients with 30 healthy controls,age(18-52 years old) and sex matched.Exclusion criteria were any active inflammatory condition,current anti-inflammatory treatment and MDD diagnosis(DSM-IV,MINI assessment).Physical health questionnaire for depression(PHQ-9) and perceived stress scale(PSS) were used for clinical assessment. Serum levels(sl) of inflammatory markers interleukin-6(IL-6) and prostaglandin-E2(PGE2), oxidative stress marker malonyl-dialdehyde(MDA) and anti-oxidant enzymes superoxide-dismutase(SOD) and catalase(CAT) were measured.Resting-state functional MRI(fMRI) was used to assess the changes in intrinsic brain networks in all participants. Functional connectivity maps were generated for a priori selected regions-of-interest(ROIs), including the bilateral insula, subgenual anterior cingulate(sgACC) cortex and bilateral putamen. Voxel-wise analyses in SPM served to assess the association between functional connectivity and clinical/biological variables. Results: Table 1 shows sociodemographics, biological markers and clinical characteristics of both samples. CHC patients showed increased PSS and PHQ-9 scores, IL-6 and PGE2 sl, and antioxidant system activation compared to controls. Subtle case-control differences in functional connectivity were also observed with patients showing decreased connectivity between insula and cingulate cortex, caudate nucleus and anterior prefrontal cortex; between sgACC and orbitofrontal cortex; between putamen, thalamus and temporal regions. By contrast, patients showed increased connectivity between insula and temporal cortex; sgACC and precuneus and temporal cortex; putamen, supramarginal gyrus and postcentral cortex. PHQ-9 and PSS scores were positive correlated only with PGE2 sl(r = 0.298, p = 0.019 and r = 0.245, p = 0.055 respectively).Interestingly, PSS and PHQ-9 scores were positively associated with connectivity between putamen and insula(peak correlation at MNI x = 32,y = 20,z = −20; cluster size = 11.9 ml; T = 4.8, p<0.0001; and x = 44,y = −8,z = −4;cluster size = 2.9 ml; T = 5.0, p<0.0001,respectively). PGE2 was also correlated with functional connectivity between putamen and insula (peak correlation at MNI x = 28,y = −6,z = 6; cluster size = 9.6 ml; T = 3.5, p<0.0001). Nevertheless, PGE2 did not mediate the correlation between PSS nor PHQ-9 and connectivity (t = 1.47,p = 0.141 and t = 1.37,p = 0.171,respectively). Conclusions: Patients with CHC exhibited increased perceived stress and depressive symptoms,which were associated with inflammatory markers together with alterations in connectivity between the insula to putamen,areas involved in interoceptive integration,emotional awareness, and orientation of motivational state. The absence of MDD in the study sample may explain the lack of oxidative stress in CHC patients.
dc.language.isoENen_US
dc.title.enChronic inflammation in hepatitis C patients is associated with increased perceived stress and abnormal connectivity between insula and basal ganglia
dc.typeCommunication dans un congrès avec actesen_US
dc.identifier.doi10.1016/j.euroneuro.2018.11.284en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.pageS163-S164en_US
bordeaux.volumeVolume 29en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issueSupplément 1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.conference.title31. ECNP Congressen_US
bordeaux.countryesen_US
bordeaux.title.proceedingEuropean Neuropsychopharmacologyen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.conference.cityBarcelogneen_US
bordeaux.peerReviewedouien_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.date=2018-10&amp;rft.volume=Volume%2029&amp;rft.issue=Suppl%C3%A9ment%201&amp;rft.spage=S163-S164&amp;rft.epage=S163-S164&amp;rft.eissn=0924-977X&amp;rft.issn=0924-977X&amp;rft.au=ORIOLO,%20G.&amp;NAVINES,%20R.&amp;BLANCO,%20L.&amp;MARTIN-HERNANDEZ,%20D.&amp;MARINO,%20Z.&amp;rft.genre=proceeding


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