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Effects of saffron extract supplementation on mood, well-being, and response to a psychosocial stressor in healthy adults: a randomized, double-blind, parallel group, clinical trial

dc.rights.licenseopenen_US
dc.contributor.authorJACKSON, Philippa
dc.contributor.authorFORSTER, Joanne
dc.contributor.authorKHAN, Julie
dc.contributor.authorPOUCHIEU, Camille
dc.contributor.authorDUBREUIL, Severine
dc.contributor.authorGAUDOUT, David
dc.contributor.authorMORAS, Benjamin
dc.contributor.authorPOURTAU, Line
dc.contributor.authorJOFFRE, Florent
dc.contributor.authorVAYSSE, Carole
dc.contributor.authorBERTRAND, Karene
dc.contributor.authorABROUS, Helene
dc.contributor.authorVAUZOUR, David
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBROSSAUD, Julie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCORCUFF, Jean-Benoit
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
dc.contributor.authorKENNEDY, David
dc.date.accessioned2021-09-21T12:39:19Z
dc.date.available2021-09-21T12:39:19Z
dc.date.issued2021-02
dc.identifier.issn2296-861Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112294
dc.description.abstractEnAnxiety, stress, and low mood are closely related and may contribute to depressive symptoms. Among non-pharmacological solutions to improve subclinical mood symptoms and resilience to stress, natural products such as saffron—identified as promising following preliminary beneficial effects in major depressive disorder—represent a relevant strategy. This study aimed to assess the efficacy of 8 weeks' supplementation with 30 mg standardized saffron extract on emotional well-being in healthy adults with subclinical feelings of low mood and anxiety and/or stress and evaluate the acute effect of saffron in response to a lab-based psychosocial stressor. The study adopted a double-blind, randomized, parallel groups design in which 56 healthy male and female individuals (18–54 years) received either a saffron extract or a placebo for 8 weeks. Chronic effects of saffron on subjective anxiety, stress, and depressive feelings were assessed using a questionnaire battery [including Profile of Mood State-2, (POMS)] and acute effects in response to a lab-based psychosocial stressor were measured through psychological and physiological parameters. Urinary crocetin levels were quantified. Participants who received the saffron extract reported reduced depression scores and improved social relationships at the end of the study. Urinary crocetin levels increased significantly with saffron supplementation and were correlated with change in depression scores. The typical stress-induced decrease in heart rate variability (HRV) during exposure to the stressor was attenuated following acute saffron intake. Saffron extract appears to improve subclinical depressive symptoms in healthy individuals and may contribute to increased resilience against the development of stress-related psychiatric disorders. Clinical trials number: NCT03639831.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enSaffron
dc.subject.enDepression
dc.subject.enAnxiety
dc.subject.enHeart rate variability
dc.subject.enCrocetin
dc.title.enEffects of saffron extract supplementation on mood, well-being, and response to a psychosocial stressor in healthy adults: a randomized, double-blind, parallel group, clinical trial
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/fnut.2020.606124en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33598475en_US
bordeaux.journalFrontiers in nutritionen_US
bordeaux.volume7en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20nutrition&rft.date=2021-02&rft.volume=7&rft.eissn=2296-861X&rft.issn=2296-861X&rft.au=JACKSON,%20Philippa&FORSTER,%20Joanne&KHAN,%20Julie&POUCHIEU,%20Camille&DUBREUIL,%20Severine&rft.genre=article


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