Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MONCHAUX DE OLIVEIRA, Camille | |
| dc.contributor.author | POURTAU, Line | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | VANCASSEL, Sylvie | |
| dc.contributor.author | POUCHIEU, Camille | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CAPURON, Lucile
IDREF: 167018736 | |
| dc.contributor.author | GAUDOUT, David | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CASTANON, Nathalie | |
| dc.date.accessioned | 2021-09-21T06:52:31Z | |
| dc.date.available | 2021-09-21T06:52:31Z | |
| dc.date.issued | 2021-03 | |
| dc.identifier.issn | 2072-6643 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112260 | |
| dc.description.abstractEn | Depressive disorders represent a major public health concern and display a continuously rising prevalence. Importantly, a large proportion of patients develops aversive side effects and/or does not respond properly to conventional antidepressants. These issues highlight the need to identify further therapeutic strategies, including nutritional approaches using natural plant extracts with known beneficial impacts on health. In that context, growing evidence suggests that saffron could be a particularly promising candidate. This preclinical study aimed therefore to test its antidepressant-like properties in mice and to decipher the underlying mechanisms by focusing on monoaminergic neurotransmission, due to its strong implication in mood disorders. For this purpose, the behavioral and neurobiochemical impact of a saffron extract, Safr’Inside™ (6.5 mg/kg per os) was measured in naïve mice. Saffron extract reduced depressive-like behavior in the forced swim test. This behavioral improvement was associated with neurobiological modifications, particularly changes in serotonergic and dopaminergic neurotransmission, suggesting that Safr’Inside™ may share common targets with conventional pharmacological antidepressants. This study provides useful information on the therapeutic relevance of nutritional interventions with saffron extracts to improve management of mood disorders. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Mood disorders | |
| dc.subject.en | Nutritional interventions | |
| dc.subject.en | Saffron extract | |
| dc.subject.en | Safr’InsideTM | |
| dc.subject.en | Depressive-like behavior | |
| dc.subject.en | Monoaminergic neurotransmission | |
| dc.title.en | Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/nu13030904 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 33799507 | en_US |
| bordeaux.journal | Nutrients | en_US |
| bordeaux.page | 904 | en_US |
| bordeaux.volume | 13 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutrients&rft.date=2021-03&rft.volume=13&rft.issue=3&rft.spage=904&rft.epage=904&rft.eissn=2072-6643&rft.issn=2072-6643&rft.au=MONCHAUX%20DE%20OLIVEIRA,%20Camille&POURTAU,%20Line&VANCASSEL,%20Sylvie&POUCHIEU,%20Camille&CAPURON,%20Lucile&rft.genre=article |
