Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits
dc.rights.license | open | en_US |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | DUCROCQ, Fabien | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | WALLE, Roman | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | CONTINI, Andrea | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | OUMMADI, Asma | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | CARABALLO, Baptiste | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | VAN DER VELDT, Suzanne | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | BOYER, Marie-Lou | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | ABY, Frank | |
dc.contributor.author | TOLENTINO-CORTEZ, Tarson | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | HELBLING, Jean Christophe | |
dc.contributor.author | MARTINE, Lucy | |
dc.contributor.author | GREGOIRE, Stephane | |
dc.contributor.author | CABARET, Stephanie | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | VANCASSEL, Sylvie | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | LAYE, Sophie | |
dc.contributor.author | KANG, Jing Xuan | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | FIORAMONTI, Xavier | |
dc.contributor.author | BERDEAUX, Olivier | |
dc.contributor.author | BARREDA-GOMEZ, Gabriel | |
dc.contributor.author | MASSON, Elodie | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | FERREIRA, Guillaume | |
dc.contributor.author | MA, David W. L. | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | BOSCH BOUJU, Clementine | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | DE SMEDT-PEYRUSSE, Veronique | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | TRIFILIEFF, Pierre | |
dc.date.accessioned | 2021-09-17T08:19:05Z | |
dc.date.available | 2021-09-17T08:19:05Z | |
dc.date.issued | 2019-01-01 | |
dc.identifier.issn | 1550-4131 | en_US |
dc.identifier.uri | oai:crossref.org:10.1016/j.cmet.2020.02.012 | |
dc.identifier.uri | oai:crossref.org:10.2139/ssrn.3382436 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112224 | |
dc.description.abstractEn | Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 Polyunsaturated Fatty Acids (PUFAs) lipid species, consistently described in these pathologies, could underlie reward-processing deficits. We show that reduced n-3 PUFA biostatus in mice leads to selective motivational deficits. Electrophysiological recordings revealed increased collateral inhibition of dopamine D2 receptor (D2R)-expressing medium spiny neurons (iMSNs) onto dopamine D1 receptor-expressing (d)MSNs in the nucleus accumbens, a main brain region for the modulation of motivation. Strikingly, transgenically preventing n-3 PUFA deficiency selectively in D2R-expressing neurons normalizes MSNs collateral inhibition and enhances motivation. These results constitute the first demonstration of a causal link between a behavioral deficit and n-3 PUFA decrease in a discrete neuronal population and suggest that lower n-3 PUFA biostatus in psychopathologies could participate to the etiology of reward-related symptoms. | |
dc.language.iso | EN | en_US |
dc.source | crossref | |
dc.subject.en | Polyunsaturated fatty acids | |
dc.subject.en | Motivation | |
dc.subject.en | Dopamine | |
dc.subject.en | Nucleus accumbens | |
dc.subject.en | Medium spiny neurons | |
dc.subject.en | Electrophysiology | |
dc.title.en | Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.2139/ssrn.3382436 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | |
bordeaux.journal | Cell Metabolism | en_US |
bordeaux.page | 755-772.e7 | en_US |
bordeaux.volume | 31 | en_US |
bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
bordeaux.issue | 4 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INRAE | en_US |
bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.import.source | dissemin | |
hal.identifier | hal-03347311 | |
hal.version | 1 | |
hal.date.transferred | 2021-09-17T14:10:56Z | |
hal.export | true | |
workflow.import.source | dissemin | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Metabolism&rft.date=2019-01-01&rft.volume=31&rft.issue=4&rft.spage=755-772.e7&rft.epage=755-772.e7&rft.eissn=1550-4131&rft.issn=1550-4131&rft.au=DUCROCQ,%20Fabien&WALLE,%20Roman&CONTINI,%20Andrea&OUMMADI,%20Asma&CARABALLO,%20Baptiste&rft.genre=article |
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