Enriched dairy fat matrix diet prevents early life lipopolysaccharide-induced spatial memory impairment at adulthood
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DINEL, Anne Laure
ORCID: 0000-0002-8668-9413 IDREF: 131872109 | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | REY, Charlotte | |
| dc.contributor.author | BAUDRY, Charlotte | |
| dc.contributor.author | FRESSANGE-MAZDA, Catherine | |
| dc.contributor.author | LE RUYET, Pascale | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | NADJAR, Agnes | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | PALLET, Veronique
ORCID: 0000-0002-9078-3269 IDREF: 066841763 | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | JOFFRE, Corinne | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| dc.date.accessioned | 2021-09-08T07:01:42Z | |
| dc.date.available | 2021-09-08T07:01:42Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1532-2823 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112139 | |
| dc.description.abstractEn | Polyunsaturated fatty acids (PUFAs) are essential fatty acids, which are critical for brain development and later life cognitive functions. The main brain PUFAs are docosahexaenoic acid (DHA) for the n-3 family and arachidonic acid (ARA) for the n-6 family, which are provided to the post-natal brain by breast milk or infant formula. Recently, the use of dairy lipids (DL) in replacement of vegetable lipids (VL) was revealed to potently promote the accretion of DHA in the developing brain. Brain DHA, in addition to be a key component of brain development, display potent anti-inflammatory activities, which protect the brain from adverse inflammatory events. In this work, we evaluated the protective effect of partial replacement of VL by DL, supplemented or not with DHA and ARA, on post-natal inflammation and its consequence on memory. Mice were fed with diets poor in vegetal n-3 PUFA (Def VL), balanced in vegetal n-3/n-6 PUFA (Bal VL), balanced in dairy lipids (Bal DL) or enriched in DHA and ARA (Supp VL; Supp DL) from the first day of gestation until adulthood. At post-natal day 14 (PND14), pups received a single administration of the endotoxin lipopolysaccharide (LPS) and brain cytokine expression, microglia phenotype and neurogenesis were measured. In a second set of experiments, memory and neurogenesis were measured at adulthood. Overall, our data showed that lipid quality of the diet modulates early life LPS effect on microglia phenotype, brain cytokine expression and neurogenesis at PND14 and memory at adulthood. In particular, Bal DL diet protects from the adverse effect of early life LPS exposure on PND14 neurogenesis and adult spatial memory. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Animals | |
| dc.subject.en | Arachidonic Acid | |
| dc.subject.en | Brain | |
| dc.subject.en | Cognition | |
| dc.subject.en | Dairy lipid | |
| dc.subject.en | DHA | |
| dc.subject.en | Dietary Fats | |
| dc.subject.en | Docosahexaenoic Acids | |
| dc.subject.en | Learning Disabilities | |
| dc.subject.en | Lipopolysaccharides | |
| dc.subject.en | LPS | |
| dc.subject.en | Mice | |
| dc.subject.en | Microglia | |
| dc.subject.en | Neurogenesis | |
| dc.subject.en | Plant Oils | |
| dc.subject.en | PUFA | |
| dc.subject.en | Spatial Memory | |
| dc.subject.en | Y maze | |
| dc.subject.en | Animals Newborn | |
| dc.subject.en | Disease Models Animal | |
| dc.title.en | Enriched dairy fat matrix diet prevents early life lipopolysaccharide-induced spatial memory impairment at adulthood | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.plefa.2016.08.013 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 27720041 | en_US |
| bordeaux.journal | Prostaglandins, Leukotrienes and Essential Fatty Acids | en_US |
| bordeaux.page | 9-18 | en_US |
| bordeaux.volume | 113 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Prostaglandins,%20Leukotrienes%20and%20Essential%20Fatty%20Acids&rft.date=2016&rft.volume=113&rft.spage=9-18&rft.epage=9-18&rft.eissn=1532-2823&rft.issn=1532-2823&rft.au=DINEL,%20Anne%20Laure&REY,%20Charlotte&BAUDRY,%20Charlotte&FRESSANGE-MAZDA,%20Catherine&LE%20RUYET,%20Pascale&rft.genre=article |
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