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Modulation of brain PUFA content in different experimental models of mice
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | JOFFRE, Corinne | |
| dc.contributor.author | GREGOIRE, Stephane | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DE SMEDT-PEYRUSSE, Veronique | |
| dc.contributor.author | ACAR, Niyazi | |
| dc.contributor.author | BRETILLON, Lionel | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | NADJAR, Agnes | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| dc.date.accessioned | 2021-09-08T06:56:00Z | |
| dc.date.available | 2021-09-08T06:56:00Z | |
| dc.date.issued | 2016-11 | |
| dc.identifier.issn | 1532-2823 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112138 | |
| dc.description.abstractEn | The relative amounts of arachidonic acid (AA) and docosahexaenoic acid (DHA) govern the different functions of the brain. Their brain levels depend on structures considered, on fatty acid dietary supply and the age of animals. To have a better overview of the different models available in the literature we here compared the brain fatty acid composition in various mice models (C57BL/6J, CD1, Fat-1, SAMP8 mice) fed with different n-3 PUFA diets (deficient, balanced, enriched) in adults and aged animals. Our results demonstrated that brain AA and DHA content is 1) structure-dependent; 2) strain-specific; 3) differently affected by dietary approaches when compared to genetic model of PUFA modulation; 4) different in n-3 PUFA deficient aged C57BL6/J when compared to SAMP8 mouse model of aging. From these experiments, we highlight the difficulty to compare results obtained in different mouse models, different strains, different brain regions and different ages. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Aging | |
| dc.subject.en | Animals | |
| dc.subject.en | Arachidonic Acid | |
| dc.subject.en | Arachidonic acid (AA) | |
| dc.subject.en | Brain Chemistry | |
| dc.subject.en | Brain regions | |
| dc.subject.en | Brain Stem | |
| dc.subject.en | Cerebellum | |
| dc.subject.en | Cerebral Cortex | |
| dc.subject.en | Docosahexaenoic acid (DHA) | |
| dc.subject.en | Docosahexaenoic Acids | |
| dc.subject.en | Fat-1 mice | |
| dc.subject.en | Female | |
| dc.subject.en | Hippocampus | |
| dc.subject.en | Hypothalamus | |
| dc.subject.en | Male | |
| dc.subject.en | Mice | |
| dc.subject.en | N-3 PUFA | |
| dc.subject.en | Prefrontal Cortex | |
| dc.subject.en | SAMP8 mice | |
| dc.subject.en | Dietary Fats Unsaturated | |
| dc.subject.en | Mice Inbred C57BL | |
| dc.subject.en | Models Theoretical | |
| dc.title.en | Modulation of brain PUFA content in different experimental models of mice | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.plefa.2016.09.003 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 27926457 | en_US |
| bordeaux.journal | Prostaglandins, Leukotrienes and Essential Fatty Acids | en_US |
| bordeaux.page | 1-10 | en_US |
| bordeaux.volume | 114 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Prostaglandins,%20Leukotrienes%20and%20Essential%20Fatty%20Acids&rft.date=2016-11&rft.volume=114&rft.spage=1-10&rft.epage=1-10&rft.eissn=1532-2823&rft.issn=1532-2823&rft.au=JOFFRE,%20Corinne&GREGOIRE,%20Stephane&DE%20SMEDT-PEYRUSSE,%20Veronique&ACAR,%20Niyazi&BRETILLON,%20Lionel&rft.genre=article |
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