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dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDELPECH, Jean-Christophe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorTHOMAZEAU, Aurore
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMADORE, Charlotte
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOSCH BOUJU, Clementine
ORCID: 0000-0001-8869-768X
IDREF: 156530244
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLARRIEU, Thomas
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLACABANNE, Chloe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorREMUS-BOREL, Julie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAUBERT, Agnes
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJOFFRE, Corinne
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorNADJAR, Agnes
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
dc.date.accessioned2021-09-08T06:49:07Z
dc.date.available2021-09-08T06:49:07Z
dc.date.issued2015-11
dc.identifier.issn1740-634Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112137
dc.description.abstractEnDietary n-3 polyunsaturated fatty acids (PUFAs) are critical components of inflammatory response and memory impairment. However, the mechanisms underlying the sensitizing effects of low n-3 PUFAs in the brain for the development of memory impairment following inflammation are still poorly understood. In this study, we examined how a 2-month n-3 PUFAs deficiency from pre-puberty to adulthood could increase vulnerability to the effect of inflammatory event on spatial memory in mice. Mice were given diets balanced or deficient in n-3 PUFAs for a 2-month period starting at post-natal day 21, followed by a peripheral administration of lipopolysaccharide (LPS), a bacterial endotoxin, at adulthood. We first showed that spatial memory performance was altered after LPS challenge only in n-3 PUFA-deficient mice that displayed lower n-3/n-6 PUFA ratio in the hippocampus. Importantly, long-term depression (LTD), but not long-term potentiation (LTP) was impaired in the hippocampus of LPS-treated n-3 PUFA-deficient mice. Proinflammatory cytokine levels were increased in the plasma of both n-3 PUFA-deficient and n-3 PUFA-balanced mice. However, only n-3 PUFA-balanced mice showed an increase in cytokine expression in the hippocampus in response to LPS. In addition, n-3 PUFA-deficient mice displayed higher glucocorticoid levels in response to LPS as compared with n-3 PUFA-balanced mice. These results indicate a role for n-3 PUFA imbalance in the sensitization of the hippocampal synaptic plasticity to inflammatory stimuli, which is likely to contribute to spatial memory impairment.
dc.language.isoENen_US
dc.subject.enAnimals
dc.subject.enCorticosterone
dc.subject.enCytokines
dc.subject.enDendritic Spines
dc.subject.enDisease Models
dc.subject.enAnimal
dc.subject.enGene Expression Regulation
dc.subject.enHippocampus
dc.subject.enInflammation
dc.subject.enLipopolysaccharides
dc.subject.enLong-Term Synaptic Depression
dc.subject.enMale
dc.subject.enMaze Learning
dc.subject.enMemory Disorders
dc.subject.enMice
dc.subject.enNeurons
dc.subject.enPatch-Clamp Techniques
dc.subject.enSilver Staining
dc.subject.enAnimals Newborn
dc.subject.enFatty Acids Omega-3
dc.subject.enMice Inbred C57BL
dc.title.enDietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/npp.2015.127en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed25948102en_US
bordeaux.journalNeuropsychopharmacologyen_US
bordeaux.page2774-2787en_US
bordeaux.volume40en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuropsychopharmacology&rft.date=2015-11&rft.volume=40&rft.issue=12&rft.spage=2774-2787&rft.epage=2774-2787&rft.eissn=1740-634X&rft.issn=1740-634X&rft.au=DELPECH,%20Jean-Christophe&THOMAZEAU,%20Aurore&MADORE,%20Charlotte&BOSCH%20BOUJU,%20Clementine&LARRIEU,%20Thomas&rft.genre=article


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