Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DELPECH, Jean-Christophe | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MADORE, Charlotte | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | JOFFRE, Corinne | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | AUBERT, Agnes | |
| dc.contributor.author | KANG, Jing Xuan | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | NADJAR, Agnes | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| dc.date.accessioned | 2021-09-06T14:58:52Z | |
| dc.date.available | 2021-09-06T14:58:52Z | |
| dc.date.issued | 2015-02 | |
| dc.identifier.issn | 1740-634X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112117 | |
| dc.description.abstractEn | Polyunsaturated fatty acids (PUFAs) display immunomodulatory properties in the brain, n-3 PUFAs being able to reduce inflammation whereas n-6 PUFAs are more pro-inflammatory. It has been extensively demonstrated that exposure to a peripheral immune challenge leads to the production and release of inflammatory mediators in the brain in association with cognitive deficits. The question arises whether n-3 PUFA supplementation could downregulate the brain inflammatory response and subsequent cognitive alterations. In this study, we used a genetically modified mouse line carrying the fat-1 gene from the roundworm Caenorhabditis elegans, encoding an n-3 PUFA desaturase that catalyzes conversion of n-6 into n-3 PUFA. Consequently, these mice display endogenously elevated n-3 PUFA tissue contents. Fat-1 mice or wild-type (WT) littermates were injected peripherally with lipopolysaccharide (LPS), a bacterial endotoxin, to induce an inflammatory episode. Our results showed that LPS altered differently the phenotype of microglia and the expression of cytokines and chemokines in Fat-1 and WT mice. In Fat-1 mice, pro-inflammatory factors synthesis was lowered compared with WT mice, whereas anti-inflammatory mechanisms were favored 24 h after LPS treatment. Moreover, LPS injection impaired spatial memory in WT mice, whereas interestingly, the Fat-1 mice showed normal cognitive performances. All together, these data suggest that the central n-3 PUFA increase observed in Fat-1 mice modulated the brain innate immune system activity, leading to the protection of animals against LPS-induced pro-inflammatory cytokine production and subsequent spatial memory alteration. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Animals | |
| dc.subject.en | Brain | |
| dc.subject.en | Caenorhabditis elegans Proteins | |
| dc.subject.en | Cytokines | |
| dc.subject.en | Fatty Acid Desaturases | |
| dc.subject.en | Hippocampus | |
| dc.subject.en | Illness Behavior | |
| dc.subject.en | Inflammation | |
| dc.subject.en | Inflammation Mediators | |
| dc.subject.en | Lipopolysaccharides | |
| dc.subject.en | Male | |
| dc.subject.en | Maze Learning | |
| dc.subject.en | Memory Disorders | |
| dc.subject.en | Mice | |
| dc.subject.en | Microglia | |
| dc.subject.en | Phenotype | |
| dc.subject.en | Spatial Memory | |
| dc.subject.en | Fatty Acids Omega-3 | |
| dc.subject.en | Fatty Acids Omega-6 | |
| dc.subject.en | Mice Transgenic | |
| dc.title.en | Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1038/npp.2014.196 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 25228141 | en_US |
| bordeaux.journal | Neuropsychopharmacology | en_US |
| bordeaux.page | 525-536 | en_US |
| bordeaux.volume | 40 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Recherche Agronomique | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuropsychopharmacology&rft.date=2015-02&rft.volume=40&rft.issue=3&rft.spage=525-536&rft.epage=525-536&rft.eissn=1740-634X&rft.issn=1740-634X&rft.au=DELPECH,%20Jean-Christophe&MADORE,%20Charlotte&JOFFRE,%20Corinne&AUBERT,%20Agnes&KANG,%20Jing%20Xuan&rft.genre=article |
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