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The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3
| dc.rights.license | open | en_US |
| dc.contributor.author | FIORITI, Luana | |
| dc.contributor.author | MYERS, Cory | |
| dc.contributor.author | HUANG, Yan-You | |
| dc.contributor.author | LI, Xiang | |
| dc.contributor.author | STEPHAN, Joseph S. | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | TRIFILIEFF, Pierre | |
| dc.contributor.author | COLNAGHI, Luca | |
| dc.contributor.author | KOSMIDIS, Stylianos | |
| dc.contributor.author | DRISALDI, Bettina | |
| dc.contributor.author | PAVLOPOULOS, Elias | |
| dc.contributor.author | KANDEL, Eric R. | |
| dc.date.accessioned | 2021-09-06T14:48:39Z | |
| dc.date.available | 2021-09-06T14:48:39Z | |
| dc.date.issued | 2015-06-17 | |
| dc.identifier.issn | 1097-4199 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112115 | |
| dc.description.abstractEn | Consolidation of long-term memories depends on de novo protein synthesis. Several translational regulators have been identified, and their contribution to the formation of memory has been assessed in the mouse hippocampus. None of them, however, has been implicated in the persistence of memory. Although persistence is a key feature of long-term memory, how this occurs, despite the rapid turnover of its molecular substrates, is poorly understood. Here we find that both memory storage and its underlying synaptic plasticity are mediated by the increase in level and in the aggregation of the prion-like translational regulator CPEB3 (cytoplasmic polyadenylation element-binding protein). Genetic ablation of CPEB3 impairs the maintenance of both hippocampal long-term potentiation and hippocampus-dependent spatial memory. We propose a model whereby persistence of long-term memory results from the assembly of CPEB3 into aggregates. These aggregates serve as functional prions and regulate local protein synthesis necessary for the maintenance of long-term memory. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Animals | |
| dc.subject.en | Anxiety | |
| dc.subject.en | Exploratory Behavior | |
| dc.subject.en | Fear | |
| dc.subject.en | Glutamic Acid | |
| dc.subject.en | Hippocampus | |
| dc.subject.en | In Vitro Techniques | |
| dc.subject.en | Locomotion | |
| dc.subject.en | Long-Term Potentiation | |
| dc.subject.en | Male | |
| dc.subject.en | Maze Learning | |
| dc.subject.en | Memory | |
| dc.subject.en | Mice | |
| dc.subject.en | Mutation | |
| dc.subject.en | Neurons | |
| dc.subject.en | Phosphopyruvate Hydratase | |
| dc.subject.en | Reaction Time | |
| dc.subject.en | RNA-Binding Proteins | |
| dc.subject.en | Mice Inbred C57BL | |
| dc.subject.en | Mice Transgenic | |
| dc.subject.en | Conditioning Psychological | |
| dc.title.en | The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3 | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.neuron.2015.05.021 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 26074003 | en_US |
| bordeaux.journal | Neuron | en_US |
| bordeaux.page | 1433-1448 | en_US |
| bordeaux.volume | 86 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuron&rft.date=2015-06-17&rft.volume=86&rft.issue=6&rft.spage=1433-1448&rft.epage=1433-1448&rft.eissn=1097-4199&rft.issn=1097-4199&rft.au=FIORITI,%20Luana&MYERS,%20Cory&HUANG,%20Yan-You&LI,%20Xiang&STEPHAN,%20Joseph%20S.&rft.genre=article |
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