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dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorTRIFILIEFF, Pierre
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDUCROCQ, Fabien
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorVAN DER VELDT, Suzanne
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMARTINEZ, Diana
dc.date.accessioned2021-09-06T08:10:21Z
dc.date.available2021-09-06T08:10:21Z
dc.date.issued2017-01
dc.identifier.issn1558-4623en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112086
dc.description.abstractEnPositron emission tomography (PET) imaging consistently shows blunted striatal dopamine release and decreased dopamine D2 receptor availability in addiction. Here, we review the preclinical and clinical studies indicating that this neurobiological phenotype is likely to be both a consequence of chronic drug consumption and a vulnerability factor in the development of addiction. We propose that, behaviorally, blunted striatal dopamine transmission could reflect the increased impulsivity and altered cost/benefit computations that are associated with addiction. The factors that influence blunted striatal dopamine transmission in addiction are unknown. Herein, we give an overview of various factors, genetic, environmental, and social, that are known to affect dopamine transmission and that have been associated with the vulnerability to develop addiction. Altogether, these data suggest that blunted dopamine transmission and decreased D2 receptor availability are biomarkers both for the development of addiction and resistance to treatment. These findings support the view that blunted dopamine reflects impulsive behavior and deficits in motivation, which lead to the escalation of drug use.
dc.language.isoENen_US
dc.subject.enAnimals
dc.subject.enBehavior
dc.subject.enAddictive
dc.subject.enDopamine
dc.subject.enHumans
dc.subject.enPositron-Emission Tomography
dc.subject.enSynaptic Transmission
dc.title.enBlunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior
dc.typeArticle de revueen_US
dc.identifier.doi10.1053/j.semnuclmed.2016.09.003en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed27987559en_US
bordeaux.journalSeminars in Nuclear Medicineen_US
bordeaux.page64-74en_US
bordeaux.volume47en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Seminars%20in%20Nuclear%20Medicine&rft.date=2017-01&rft.volume=47&rft.issue=1&rft.spage=64-74&rft.epage=64-74&rft.eissn=1558-4623&rft.issn=1558-4623&rft.au=TRIFILIEFF,%20Pierre&DUCROCQ,%20Fabien&VAN%20DER%20VELDT,%20Suzanne&MARTINEZ,%20Diana&rft.genre=article


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