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Reward-related brain activity and behavior are associated with peripheral ghrelin levels in obesity

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOGDANOV, Volodymyr B.
dc.contributor.authorBOGDANOVA, Olena V.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDEXPERT, Sandra
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDELGADO, Maria Ines
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBEYER, Helen
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAUBERT, Agnes
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorDILHARREGUY, Bixente
dc.contributor.authorBEAU, Cedric
dc.contributor.authorFORESTIER, Damien
dc.contributor.authorLEDAGUENEL, Patrick
dc.contributor.authorMAGNE, Eric
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
dc.contributor.authorFELGER, Jennifer
dc.contributor.authorPAGNONI, Giuseppe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
dc.date.accessioned2021-09-03T13:24:50Z
dc.date.available2021-09-03T13:24:50Z
dc.date.issued2020
dc.identifier.issn1873-3360en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112067
dc.description.abstractEnBACKGROUND/OBJECTIVES: While excessive food consumption represents a key factor in the development of obesity, the underlying mechanisms are still unclear. Ghrelin, a gut-brain hormone involved in the regulation of appetite, is impaired in obesity. In addition to its role in eating behavior, this hormone was shown to affect brain regions controlling reward, including the striatum and prefrontal cortex, and there is strong evidence of impaired reward processing in obesity. The present study investigated the possibility that disrupted reward-related brain activity in obesity relates to ghrelin deficiency. SUBJECTS/METHODS: Fifteen severely obese subjects (BMI > 35 kg/m2) and fifteen healthy non-obese control subjects (BMI < 30 kg/m2) were recruited. A guessing-task paradigm, previously shown to activate the ventral striatum, was used to assess reward-related brain neural activity by functional magnetic resonance imaging (fMRI). Fasting blood samples were collected for the measurement of circulating ghrelin. RESULTS: Significant activations in the ventral striatum, ventromedial prefrontal cortex and extrastriate visual cortex were elicited by the fMRI task in both obese and control subjects. In addition, greater reward-related activations were present in the dorsolateral prefrontal cortex, and precuneus/posterior cingulate of obese subjects compared to controls. Obese subjects exhibited longer choice times after repeated reward and lower circulating ghrelin levels than lean controls. Reduced ghrelin levels significantly predicted slower post-reward choices and reward-related hyperactivity in dorsolateral prefrontal cortices in obese subjects. CONCLUSION: This study provides evidence of association between circulating ghrelin and reward-related brain activity in obesity and encourages further exploration of the role of ghrelin system in altered eating behavior in obesity.
dc.description.sponsorshipRôle de l'Inflammation dans la Symptomatologie Neuropsychiatrique chez le Sujet Obèse - ANR-11-JSV1-0006en_US
dc.language.isoENen_US
dc.subject.enBehavior
dc.subject.enfMRI
dc.subject.enGhrelin
dc.subject.enObesity
dc.subject.enReward
dc.title.enReward-related brain activity and behavior are associated with peripheral ghrelin levels in obesity
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.psyneuen.2019.104520en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed31786481en_US
bordeaux.journalPsychoneuroendocrinologyen_US
bordeaux.page104520en_US
bordeaux.volume112en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Psychoneuroendocrinology&amp;rft.date=2020&amp;rft.volume=112&amp;rft.spage=104520&amp;rft.epage=104520&amp;rft.eissn=1873-3360&amp;rft.issn=1873-3360&amp;rft.au=BOGDANOV,%20Volodymyr%20B.&amp;BOGDANOVA,%20Olena%20V.&amp;DEXPERT,%20Sandra&amp;DELGADO,%20Maria%20Ines&amp;BEYER,%20Helen&amp;rft.genre=article


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