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Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLEPINAY, Amandine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLARRIEU, Thomas
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJOFFRE, Corinne
dc.contributor.authorACAR, Niyazi
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorGARATE, Iciar
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCASTANON, Nathalie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
dc.contributor.authorLANGELIER, Benedicte
dc.contributor.authorGUESNET, Philippe
dc.contributor.authorBRETILLON, Lionel
dc.contributor.authorPARNET, Patricia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDARNAUDERY, Muriel
dc.date.accessioned2021-09-03T12:56:45Z
dc.date.available2021-09-03T12:56:45Z
dc.date.issued2015-03
dc.identifier.issn1873-3360en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112064
dc.description.abstractEnEpidemiological observations report an increase in fat consumption associated with low intake of n-3 relative to n-6 polyunsaturated fatty acids (PUFAs) in women of childbearing age. However, the impact of these maternal feeding habits on cognitive function in the offspring is unknown. This study aims to investigate the impact of early exposure to a high-fat diet (HFD) with an unbalanced n-6/n-3 PUFAs ratio on hippocampal function in adult rats. Furthermore, we explored the effects of perinatal HFD combined with exposure to HFD after weaning. Dams were fed a control diet (C, 12% of energy from lipids, n-6/n-3 PUFAs ratio: 5) or HFD (HF, 39% of energy from lipids, n-6/n-3 PUFAs ratio: 39) throughout gestation and lactation. At weaning, offspring were placed either on control (C-C, HF-C) or high-fat (HF-HF) diets. In adulthood, hippocampus-dependent memory was assessed using the water-maze task and potential hippocampal alterations were determined by studying PUFA levels, gene expression, neurogenesis and astrocyte morphology. Perinatal HFD induced long-lasting metabolic alterations and some changes in gene expression in the hippocampus, but had no effect on memory. In contrast, spatial memory was impaired in animals exposed to HFD during the perinatal period and maintained on this diet. HF-HF rats also exhibited low n-3 and high n-6 PUFA levels, decreased neurogenesis and downregulated expression of several plasticity-related genes in the hippocampus. To determine the contribution of the perinatal diet to the memory deficits reported in HF-HF animals, an additional experiment was conducted in which rats were only exposed to HFD starting at weaning (C-HF). Interestingly, memory performance in this group was similar to controls. Overall, our results suggest that perinatal exposure to HFD with an unbalanced n-6/n-3 ratio sensitizes the offspring to the adverse effects of subsequent high-fat intake on hippocampal function.
dc.language.isoENen_US
dc.subject.enAnimals
dc.subject.enNewborn
dc.subject.enDiet
dc.subject.enHigh-Fat
dc.subject.enRats
dc.subject.enWistar
dc.subject.enFatty Acids Omega-3
dc.subject.enFatty Acids Omega-6
dc.title.enPerinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.psyneuen.2014.12.008en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed25614359en_US
bordeaux.journalPsychoneuroendocrinologyen_US
bordeaux.page82-93en_US
bordeaux.volume53en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
bordeaux.identifier.funderIDMinistère de l'Enseignement supérieur, de la Recherche et de l'Innovationen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychoneuroendocrinology&rft.date=2015-03&rft.volume=53&rft.spage=82-93&rft.epage=82-93&rft.eissn=1873-3360&rft.issn=1873-3360&rft.au=LEPINAY,%20Amandine&LARRIEU,%20Thomas&JOFFRE,%20Corinne&ACAR,%20Niyazi&GARATE,%20Iciar&rft.genre=article


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