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Assessment of Translocator Protein Density, as Marker of Neuroinflammation, in Major Depressive Disorder: A Pilot, Multicenter, Comparative, Controlled, Brain PET Study (INFLADEP Study)

dc.rights.licenseopenen_US
dc.contributor.authorYRONDI, Antoine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorEL-HAGE, Wissam
dc.contributor.authorMOLIERE, Fanny
dc.contributor.authorTHALAMAS, Claire
dc.contributor.authorDELCOURT, Nicolas
dc.contributor.authorSPORER, Marie
dc.contributor.authorTAIB, Simon
dc.contributor.authorSCHMITT, Laurent
dc.contributor.authorARLICOT, Nicolas
dc.contributor.authorMELIGNE, Deborah
dc.contributor.authorSOMMET, Agnes
dc.contributor.authorSALABERT, Anne S.
dc.contributor.authorGUILLAUME, Sebastien
dc.contributor.authorCOURTET, Philippe
dc.contributor.authorGALTIER, Florence
dc.contributor.authorMARIANO-GOULART, Denis
dc.contributor.authorCHAMPFLEUR, Nicolas Menjot De
dc.contributor.authorBARS, Emmanuelle Le
dc.contributor.authorDESMIDT, Thomas
dc.contributor.authorLEMAIRE, Mathieu
dc.contributor.authorCAMUS, Vincent
dc.contributor.authorSANTIAGO-RIBEIRO, Maria J.
dc.contributor.authorCOTTIER, Jean P.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorFERNANDEZ, Philippe
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMEYER, Marie
dc.contributor.authorDOUSSET, Vincent
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDOUMY, Olivier
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDELHAYE, Didier
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorPÉRAN, Patrice
dc.contributor.authorPAYOUX, Pierre
dc.contributor.authorARBUS, Christophe
dc.date.accessioned2021-09-01T14:36:03Z
dc.date.available2021-09-01T14:36:03Z
dc.date.issued2018
dc.identifier.issn1664-0640en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112041
dc.description.abstractEnBackground: Major depressive disorder (MDD) is a serious public health problem with high lifetime prevalence (4.4-20%) in the general population. The monoamine hypothesis is the most widespread etiological theory of MDD. Also, recent scientific data has emphasized the importance of immuno-inflammatory pathways in the pathophysiology of MDD. The lack of data on the magnitude of brain neuroinflammation in MDD is the main limitation of this inflammatory hypothesis. Our team has previously demonstrated the relevance of [18F] DPA-714 as a neuroinflammation biomarker in humans. We formulated the following hypotheses for the current study: (i) Neuroinflammation in MDD can be measured by [18F] DPA-714; (ii) its levels are associated with clinical severity; (iii) it is accompanied by anatomical and functional alterations within the frontal-subcortical circuits; (iv) it is a marker of treatment resistance. Methods: Depressed patients will be recruited throughout 4 centers (Bordeaux, Montpellier, Tours, and Toulouse) of the French network from 13 expert centers for resistant depression. The patient population will be divided into 3 groups: (i) experimental group-patients with current MDD (n = 20), (ii) remitted depressed group-patients in remission but still being treated (n = 20); and, (iii) control group without any history of MDD (n = 20). The primary objective will be to compare PET data (i.e., distribution pattern of neuroinflammation) between the currently depressed group and the control group. Secondary objectives will be to: (i) compare neuroinflammation across groups (currently depressed group vs. remitted depressed group vs. control group); (ii) correlate neuroinflammation with clinical severity across groups; (iii) correlate neuroinflammation with MRI parameters for structural and functional integrity across groups; (iv) correlate neuroinflammation and peripheral markers of inflammation across groups. Discussion: This study will assess the effects of antidepressants on neuroinflammation as well as its role in the treatment response. It will contribute to clarify the putative relationships between neuroinflammation quantified by brain neuroimaging techniques and peripheral markers of inflammation. Lastly, it is expected to open innovative and promising therapeutic perspectives based on anti-inflammatory strategies for the management of treatment-resistant forms of MDD commonly seen in clinical practice. Clinical trial registration (reference: NCT03314155): https://www.clinicaltrials.gov/ct2/show/NCT03314155?term=neuroinflammation&cond=depression&cntry=FR&rank=1.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCytokines
dc.subject.enDepression
dc.subject.enDepressive disorder
dc.subject.enDPA-714
dc.subject.enInflammation
dc.subject.enNeuroinflammation
dc.subject.enTSPO
dc.title.enAssessment of Translocator Protein Density, as Marker of Neuroinflammation, in Major Depressive Disorder: A Pilot, Multicenter, Comparative, Controlled, Brain PET Study (INFLADEP Study)
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/fpsyt.2018.00326en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed30087626en_US
bordeaux.journalFrontiers in Psychiatryen_US
bordeaux.page326en_US
bordeaux.volume9en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDMinistère des Solidarités et de la Santéen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Psychiatry&rft.date=2018&rft.volume=9&rft.spage=326&rft.epage=326&rft.eissn=1664-0640&rft.issn=1664-0640&rft.au=YRONDI,%20Antoine&AOUIZERATE,%20Bruno&EL-HAGE,%20Wissam&MOLIERE,%20Fanny&THALAMAS,%20Claire&rft.genre=article


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