Afficher la notice abrégée

Role of Adiposity-Driven Inflammation in Depressive Morbidity

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
IDREF: 167018736
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLASSELIN, Julie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCASTANON, Nathalie
dc.date.accessioned2021-09-01T09:04:11Z
dc.date.available2021-09-01T09:04:11Z
dc.date.issued2017
dc.identifier.issn1740-634Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/110275
dc.description.abstractEnDepression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies.
dc.description.sponsorshipRôle de l'Inflammation dans la Symptomatologie Neuropsychiatrique chez le Sujet Obèse - ANR-11-JSV1-0006en_US
dc.language.isoENen_US
dc.subject.enDepressive Disorder
dc.subject.enHumans
dc.subject.enInflammation
dc.subject.enOverweight
dc.title.enRole of Adiposity-Driven Inflammation in Depressive Morbidity
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/npp.2016.123en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed27402495en_US
bordeaux.journalNeuropsychopharmacologyen_US
bordeaux.page115-128en_US
bordeaux.volume42en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuropsychopharmacology&rft.date=2017&rft.volume=42&rft.issue=1&rft.spage=115-128&rft.epage=115-128&rft.eissn=1740-634X&rft.issn=1740-634X&rft.au=CAPURON,%20Lucile&LASSELIN,%20Julie&CASTANON,%20Nathalie&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée