Hippocampal CB1 Receptors Control Incidental Associations
| dc.rights.license | open | en_US |
| dc.contributor.author | BUSQUETS-GARCIA, Arnau | |
| dc.contributor.author | OLIVEIRA DA CRUZ, Jose F. | |
| dc.contributor.author | TERRAL, Geoffrey | |
| dc.contributor.author | PAGANO ZOTTOLA, Antonio C. | |
| dc.contributor.author | SORIA-GOMEZ, Edgar | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CONTINI, Andrea | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MARTIN, Hugo | |
| dc.contributor.author | REDON, Bastien | |
| dc.contributor.author | VARILH, Marjorie | |
| dc.contributor.author | IOANNIDOU, Christina | |
| dc.contributor.author | DRAGO, Filippo | |
| dc.contributor.author | MASSA, Federico | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FIORAMONTI, Xavier | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | TRIFILIEFF, Pierre | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FERREIRA, Guillaume | |
| dc.contributor.author | MARSICANO, Giovanni | |
| dc.date.accessioned | 2021-08-31T09:40:04Z | |
| dc.date.available | 2021-08-31T09:40:04Z | |
| dc.date.issued | 2018 | |
| dc.identifier.issn | 1097-4199 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/110263 | |
| dc.description.abstractEn | By priming brain circuits, associations between low-salience stimuli often guide future behavioral choices through a process known as mediated or inferred learning. However, the precise neurobiological mechanisms of these incidental associations are largely unknown. Using sensory preconditioning procedures, we show that type 1 cannabinoid receptors (CB1R) in hippocampal GABAergic neurons are necessary and sufficient for mediated but not direct learning. Deletion and re-expression of CB1R in hippocampal GABAergic neurons abolishes and rescues mediated learning, respectively. Interestingly, paired presentations of low-salience sensory cues induce a specific protein synthesis-dependent enhancement of hippocampal CB1R expression and facilitate long-term synaptic plasticity at inhibitory synapses. CB1R blockade or chemogenetic manipulations of hippocampal GABAergic neurons upon preconditioning affect incidental associations, as revealed by impaired mediated learning. Thus, CB1R-dependent control of inhibitory hippocampal neurotransmission mediates incidental associations, allowing future associative inference, a fundamental process for everyday life, which is altered in major neuropsychiatric diseases. VIDEO ABSTRACT. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Animals | |
| dc.subject.en | CB1 | |
| dc.subject.en | endocannabinoids | |
| dc.subject.en | GABA | |
| dc.subject.en | GABAergic Neurons | |
| dc.subject.en | higher-order associations | |
| dc.subject.en | hippocampus | |
| dc.subject.en | Hippocampus | |
| dc.subject.en | incidental learning | |
| dc.subject.en | Long-Term Synaptic Depression | |
| dc.subject.en | mediated learning | |
| dc.subject.en | Mice | |
| dc.subject.en | Neuronal Plasticity | |
| dc.subject.en | Receptor | |
| dc.subject.en | Cannabinoid | |
| dc.subject.en | Synapses | |
| dc.subject.en | Synaptic Transmission | |
| dc.subject.en | Western immunoblotting | |
| dc.subject.en | electrophysiology (LTP | |
| dc.subject.en | I-LTD) | |
| dc.title.en | Hippocampal CB1 Receptors Control Incidental Associations | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.neuron.2018.08.014 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 30174119 | en_US |
| bordeaux.journal | Neuron | en_US |
| bordeaux.page | 1247-1259.e7 | en_US |
| bordeaux.volume | 99 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.institution | INSERM | |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
| bordeaux.team | Endocannabinoïdes et Neuroadaptation | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
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