Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LABROUSSE, Virginie F. | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LEYROLLE, Quentin | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | AMADIEU, Camille | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | AUBERT, Agnes | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | SERE, Alexandra | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | COUTUREAU, Etienne | |
| dc.contributor.author | GREGOIRE, Stephane | |
| dc.contributor.author | BRETILLON, Lionel | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | PALLET, Veronique
ORCID: 0000-0002-9078-3269 IDREF: 066841763 | |
| dc.contributor.author | GRESSENS, P. | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | JOFFRE, Corinne | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | NADJAR, Agnes | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie | |
| dc.date.accessioned | 2021-08-31T08:28:12Z | |
| dc.date.available | 2021-08-31T08:28:12Z | |
| dc.date.issued | 2018 | |
| dc.identifier.issn | 1090-2139 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/110259 | |
| dc.description.abstractEn | Maternal immune activation (MIA) is a common environmental insult on the developing brain and represents a risk factor for neurodevelopmental disorders. Animal models of in utero inflammation further revealed a causal link between maternal inflammatory activation during pregnancy and behavioural impairment relevant to neurodevelopmental disorders in the offspring. Accumulating evidence point out that proinflammatory cytokines produced both in the maternal and fetal compartments are responsible for social, cognitive and emotional behavioral deficits in the offspring. Polyunsaturated fatty acids (PUFAs) are essential fatty acids with potent immunomodulatory activities. PUFAs and their bioactive derivatives can promote or inhibit many aspects of the immune and inflammatory response. PUFAs of the n-3 series ('n-3 PUFAs', also known as omega-3) exhibit anti-inflammatory/pro-resolution properties and promote immune functions, while PUFAs of the n-6 series ('n-6 PUFAs' or omega-6) favor pro-inflammatory responses. The present study aimed at providing insight into the effects of n-3 PUFAs on the consequences of MIA on brain development. We hypothesized that a reduction in n-3 PUFAs exacerbates both maternal and fetal inflammatory responses to MIA and later-life defects in memory in the offspring. Based on a lipopolysaccharide (LPS) model of MIA (LPS injection at embryonic day 17), we showed that n-3 PUFA deficiency 1) alters fatty acid composition of the fetal and adult offspring brain; 2) exacerbates maternal and fetal inflammatory processes with no significant alteration of microglia phenotype, and 3) induces spatial memory deficits in the adult offspring. We also showed a strong negative correlation between brain content in n-3 PUFA and cytokine production in MIA-exposed fetuses. Overall, our study is the first to address the deleterious effects of n-3 PUFA deficiency on brain lipid composition, inflammation and memory performances in MIA-exposed animals and indicates that it should be considered as a potent environmental risk factor for the apparition of neurodevelopmental disorders. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Animals | |
| dc.subject.en | Newborn | |
| dc.subject.en | Behavior | |
| dc.subject.en | Animal | |
| dc.subject.en | Brain | |
| dc.subject.en | Cytokines | |
| dc.subject.en | Dietary Supplements | |
| dc.subject.en | Disease Models | |
| dc.subject.en | Fatty Acids | |
| dc.subject.en | Omega-6 | |
| dc.subject.en | Female | |
| dc.subject.en | Inflammation | |
| dc.subject.en | Lipopolysaccharides | |
| dc.subject.en | LPS | |
| dc.subject.en | Memory | |
| dc.subject.en | Memory Disorders | |
| dc.subject.en | MIA | |
| dc.subject.en | Mice | |
| dc.subject.en | Inbred C57BL | |
| dc.subject.en | Microglia | |
| dc.subject.en | Neurodevelopmental Disorders | |
| dc.subject.en | Omega-3 | |
| dc.subject.en | Pregnancy | |
| dc.subject.en | Prenatal Exposure Delayed Effects | |
| dc.subject.en | PUFA | |
| dc.subject.en | Social Behavior | |
| dc.subject.en | Spatial Memory | |
| dc.title.en | Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.bbi.2018.06.004 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 29879442 | en_US |
| bordeaux.journal | Brain, Behavior, and Immunity | en_US |
| bordeaux.page | 427-440 | en_US |
| bordeaux.volume | 73 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Fondation de France | en_US |
| bordeaux.identifier.funderID | Institut National de la Recherche Agronomique | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Fondation Motrice | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.identifier.funderID | Conseil Régional, Île-de-France | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain,%20Behavior,%20and%20Immunity&rft.date=2018&rft.volume=73&rft.spage=427-440&rft.epage=427-440&rft.eissn=1090-2139&rft.issn=1090-2139&rft.au=LABROUSSE,%20Virginie%20F.&LEYROLLE,%20Quentin&AMADIEU,%20Camille&AUBERT,%20Agnes&SERE,%20Alexandra&rft.genre=article |
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