Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2
| dc.rights.license | open | en_US |
| dc.contributor.author | TOURET, Franck | |
| dc.contributor.author | DRIOUICH, Jean-Selim | |
| dc.contributor.author | COCHIN, Maxime | |
| dc.contributor.author | PETIT, Paul Remi | |
| dc.contributor.author | GILLES, Magali | |
| dc.contributor.author | BARTHELEMY, Karine | |
| dc.contributor.author | MOUREAU, Gregory | |
| hal.structure.identifier | Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION] | |
| dc.contributor.author | MAHON, Francois-Xavier | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MALVY, Denis | |
| dc.contributor.author | SOLAS, Caroline | |
| dc.contributor.author | DE LAMBALLERIE, Xavier | |
| dc.contributor.author | NOUGAIREDE, Antoine | |
| dc.date.accessioned | 2021-08-30T09:51:11Z | |
| dc.date.available | 2021-08-30T09:51:11Z | |
| dc.date.issued | 2021-07-12 | |
| dc.identifier.issn | 0166-3542 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/110250 | |
| dc.description.abstractEn | Following the emergence of SARS-CoV-2, the search for an effective and rapidly available treatment was initiated worldwide based on repurposing of available drugs. Previous reports described the antiviral activity of certain tyrosine kinase inhibitors (TKIs) targeting the Abelson kinase 2 against pathogenic coronaviruses. Imatinib, one of them, has more than twenty years of safe utilization for the treatment of hematological malignancies. In this context, Imatinib was rapidly evaluated in clinical trials against Covid-19. Here, we present the pre-clinical evaluation of imatinib in multiple models. Our results indicated that imatinib and another TKI, the masitinib, exhibit an antiviral activity in VeroE6 cells. However, imatinib was inactive in a reconstructed bronchial human airway epithelium model. In vivo, imatinib therapy failed to impair SARS-CoV-2 replication in a golden Syrian hamster model despite high concentrations in plasma and in the lung. Overall, these results do not support the use of imatinib and similar TKIs as antivirals in the treatment of Covid-19. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | SARS-CoV-2 | |
| dc.subject.en | Covid-19 | |
| dc.subject.en | Coronavirus | |
| dc.subject.en | Antivirals | |
| dc.subject.en | Tyrosine kinase inhibitor | |
| dc.subject.en | Imatinib | |
| dc.title.en | Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2 | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.antiviral.2021.105137 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34265358 | en_US |
| bordeaux.journal | Antiviral Research | en_US |
| bordeaux.page | 105137 | en_US |
| bordeaux.volume | 193 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | IDLIC | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Fondation de France | en_US |
| hal.identifier | hal-03328717 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-08-30T09:51:16Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Antiviral%20Research&rft.date=2021-07-12&rft.volume=193&rft.spage=105137&rft.epage=105137&rft.eissn=0166-3542&rft.issn=0166-3542&rft.au=TOURET,%20Franck&DRIOUICH,%20Jean-Selim&COCHIN,%20Maxime&PETIT,%20Paul%20Remi&GILLES,%20Magali&rft.genre=article |
