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Occupational Insecticide Exposure and Risk of Non-Hodgkin Lymphoma: A Pooled Case-Control Study from the InterLymph Consortium

dc.rights.licenseopenen_US
dc.contributor.authorDE ROOS, Anne-Claire J.
dc.contributor.authorSCHINASI, Leah H.
dc.contributor.authorMILIGI, Lucia
dc.contributor.authorCERHAN, James R.
dc.contributor.authorBHATTI, Parveen
dc.contributor.authorMANNETJE, Andrea't
dc.contributor.authorBARIS, Dalsu
dc.contributor.authorBENAVENTE, Yolanda
dc.contributor.authorBENKE, Geza
dc.contributor.authorCLAVEL, Jacqueline
dc.contributor.authorCASABONNE, Delphine
dc.contributor.authorFRITSCHI, Lin
dc.contributor.authorHOFMANN, Jonathan N.
dc.contributor.authorHUYNH, Tran
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONNEREAU, Alain
dc.contributor.authorPIRO, Sara
dc.contributor.authorSLAGER, Susan L.
dc.contributor.authorVAJDIC, Claire M.
dc.contributor.authorWANG, Sophia S.
dc.contributor.authorZHANG, Yawei
dc.contributor.authorBERNSTEIN, Leslie
dc.contributor.authorCOCCO, Pierluigi
dc.date.accessioned2021-08-27T13:38:43Z
dc.date.available2021-08-27T13:38:43Z
dc.date.issued2021-07-16
dc.identifier.issn0020-7136en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/110232
dc.description.abstractEnEvidence for the human health effects of pesticides is needed to inform risk assessment. We studied the relationship between occupational insecticide use and risk of non-Hodgkin lymphoma (NHL) by pooling data from nine case-control studies participating in the InterLymph Consortium, including 7909 cases and 8644 controls from North America, the European Union, and Australia. Insecticide use was coded using self-report or expert assessment, for insecticide groups (e.g., organophosphates, pyrethroids) and active ingredients (e.g., malathion, permethrin). Associations with insecticides were estimated using logistic regression to produce odds ratios (ORs) and 95% confidence intervals (CI) for all NHL and NHL subtypes, with adjustment for study site, demographic factors, and use of other pesticides. Occupational insecticide use, overall, was not associated with risk of NHL. Use of organophosphate insecticides was associated with increased risk of all NHL and the subtype follicular lymphoma, and an association was found with diazinon, in particular (ever use: OR=2.05, 95% CI: 1.24-3.37). The carbamate insecticide, carbaryl, was associated with risk of all NHL, and the strongest associations were found with T-cell NHL for ever-use (OR=2.44, 95% CI: 1.13-5.28) and longer duration (>8 years vs. never: OR=2.90, 95% CI: 1.02-8.25). There was no association of NHL with other broad groups of insecticides, including organochlorine and pyrethroids, and some inverse associations were estimated in relation to historical DDT use. Our findings contribute to the totality of evidence available to help inform risk decisions by public health and regulatory agencies - of importance given continued, widespread use of organophosphate and carbamate insecticides. This article is protected by copyright. All rights reserved.
dc.language.isoENen_US
dc.subject.enChronic lymphocytic leukemia
dc.subject.enInsecticide
dc.subject.enMultiple myeloma
dc.subject.enNon-Hodgkin lymphoma
dc.subject.enPesticide
dc.title.enOccupational Insecticide Exposure and Risk of Non-Hodgkin Lymphoma: A Pooled Case-Control Study from the InterLymph Consortium
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/ijc.33740en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34270795en_US
bordeaux.journalInternational Journal of Canceren_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDNational Cancer Instituteen_US
hal.identifierhal-03327829
hal.version1
hal.date.transferred2021-08-27T13:38:47Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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