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Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status

dc.rights.licenseopenen_US
dc.contributor.authorNERPIN, Elisabet
dc.contributor.authorFERREIRA, Diogenes Seraphim
dc.contributor.authorWEYLER, Joost
dc.contributor.authorSCHLUNNSEN, Vivi
dc.contributor.authorJOGI, Rain
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAHERISON-SEMJEN, Chantal
dc.contributor.authorGISLASSON, Thorainn
dc.contributor.authorDEMOLY, Pascal
dc.contributor.authorHEINRICH, Joachim
dc.contributor.authorNOWAK, Dennis
dc.contributor.authorCORSICO, Angelo
dc.contributor.authorACCORDINI, Simone
dc.contributor.authorMARCON, Alessandro
dc.contributor.authorSQUILLACIOTI, Giulia
dc.contributor.authorOLIVIERI, Mario
dc.contributor.authorNIELSEN, Rune
dc.contributor.authorJOHANNESSEN, Ane
dc.contributor.authorGOMEZ REAL, Francisco
dc.contributor.authorGARCIA-AYMERICH, Judith
dc.contributor.authorURRUTIA, Isabel
dc.contributor.authorPEREIRA-VEGA, Antonio
dc.contributor.authorGULLON, Jose Antonio
dc.contributor.authorOLIN, Anna-Carin
dc.contributor.authorFORSBERG, Bertil
dc.contributor.authorEMILSSON, Ossur Ingi
dc.contributor.authorPIN, Isabelle
dc.contributor.authorJARVIS, Deborah
dc.contributor.authorJANSON, Christer
dc.contributor.authorMALINOVSCHI, Andrei
dc.date.accessioned2021-08-23T09:44:43Z
dc.date.available2021-08-23T09:44:43Z
dc.date.issued2021-05-18
dc.identifier.issn1939-4551 (Print) 1939-4551en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/110188
dc.description.abstractEnBACKGROUND: Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients. The associations of FeNO with lung function decline and bronchodilator (BD) response have been studied only scarcely in large populations. OBJECTIVES: To study the association between FeNO and a) retrospective lung function decline over 20 years, and b) lung function response to BD among asthmatic subjects compared with non-asthmatic subjects and with regards to current smoking and sex. METHODS: Longitudinal analyses of previous lung function decline and FeNO level at follow-up and cross-sectional analyses of BD response and FeNO levels in 4257 participants (651 asthmatics) from the European Community Respiratory Health Survey. RESULTS: Among asthmatic subjects, higher percentage declines of FEV(1) and FEV(1)/FVC were associated with higher FeNO levels (p = 0.001 for both) at follow-up. These correlations were found mainly among non-smoking individuals (p = 0.001) and females (p = 0.001) in stratified analyses.Percentage increase in FEV(1) after BD was positively associated with FeNO levels in non-asthmatic subjects. Further, after stratified for sex and smoking separately, a positive association was seen between FEV(1) and FeNO levels in non-smokers and women, regardless of asthma status. CONCLUSIONS: We found a relationship between elevated FeNO and larger FEV(1) decline over 20 years among subjects with asthma who were non-smokers or women. The association between elevated FeNO levels and larger BD response was found in both non-asthmatic and asthmatic subjects, mainly in women and non-smoking subjects.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enBronchodilatation
dc.subject.enEpidemiology
dc.subject.enFeNO
dc.subject.enLung function
dc.title.enBronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.waojou.2021.100544en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34093956en_US
bordeaux.journalWorld Allergy Organization Journalen_US
bordeaux.page100544en_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03337837
hal.version1
hal.date.transferred2021-09-08T09:29:32Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=World%20Allergy%20Organization%20Journal&rft.date=2021-05-18&rft.volume=14&rft.issue=5&rft.spage=100544&rft.epage=100544&rft.eissn=1939-4551%20(Print)%201939-4551&rft.issn=1939-4551%20(Print)%201939-4551&rft.au=NERPIN,%20Elisabet&FERREIRA,%20Diogenes%20Seraphim&WEYLER,%20Joost&SCHLUNNSEN,%20Vivi&JOGI,%20Rain&rft.genre=article


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