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dc.rights.licenseopenen_US
dc.contributor.authorMASSONGO, M.
dc.contributor.authorNGANDO, L.
dc.contributor.authorPEFURA YONE, E. W.
dc.contributor.authorNZOUANKEU, A.
dc.contributor.authorMBANZOUEN, W.
dc.contributor.authorFONKOUA, M. C.
dc.contributor.authorNGANDJIO, A.
dc.contributor.authorTCHATCHUENG, J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBARGER, Diana
dc.contributor.authorTEJIOKEM, M. C.
dc.date.accessioned2021-08-23T07:30:44Z
dc.date.available2021-08-23T07:30:44Z
dc.date.issued2021-05-24
dc.identifier.issn2314-6133 (Print)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/110182
dc.description.abstractEnINTRODUCTION: Antimicrobial resistance represents a growing public health threat. One of the World Health Organization's strategic objectives is "strengthening knowledge through surveillance and research." Sub-Saharan African countries are still far from achieving this objective. We aimed to estimate and compare the prevalence of antibacterial resistance in 2010 and 2017 in Cameroon. METHODS: We conducted a retrospective study on all clinical specimens cultured in Centre Pasteur du Cameroun (CPC) in 2010 and 2017. Data were extracted from the CPC's laboratory data information system software and then managed and analyzed using R. Bacterial resistance rates were calculated in each year and compared using chi-square or Fisher's tests, and relative changes were calculated. Outcomes included acquired resistance (AR), WHO priority resistant pathogens, some specific resistances of clinical interest, and resistance patterns (multi, extensively, and pan drug resistances) for five selected pathogens. RESULTS: A total of 10,218 isolates were analyzed. The overall AR rate was 96.0% (95% CI: 95.4-96.6). Most of WHO priority bacterial resistance rates increased from 2010 to 2017. The most marked increases expressed as relative changes concerned imipenem-resistant Acinetobacter (6.2% vs. 21.6%, +248.4%, p = 0.02), imipenem-resistant Pseudomonas aeruginosa (13.5% vs. 23.5%, +74.1%, p < 0.01), 3rd generation-resistant Enterobacteriaceae (23.8% vs. 40.4%, +65.8%, p < 10(-15)), methicillin-resistant Staphylococcus aureus (27.3% vs. 46.0%, +68.6%, p < 0.002), fluoroquinolone-resistant Salmonella (3.9% vs. 9.5%, +142.9%, p = 0.03), and fluoroquinolone-resistant Enterobacteriaceae (32.6% vs. 54.0%, +65.8%, p < 10(-15)). For selected pathogens, global multidrug resistance was high in 2010 and 2017 (74.9% vs. 78.0% +4.1%, p = 0.01), intensively drug resistance rate was 5.8% (7.0% vs. 4.7%; p = 0.07), and no pan drug resistance has been identified. CONCLUSION: Bacterial resistance to antibiotics of clinical relevance in Cameroon was high and appeared to increase between 2010 and 2017. There is a need for regular surveillance of antibacterial resistance to inform public health strategies and empirically inform prescription practices.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enTrends of Antibacterial Resistance at the National Reference Laboratory in Cameroon: Comparison of the Situation between 2010 and 2017
dc.typeArticle de revueen_US
dc.identifier.doi10.1155/2021/9957112en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34124266en_US
bordeaux.journalBioMed Research Internationalen_US
bordeaux.page9957112en_US
bordeaux.volume2021en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03323830
hal.version1
hal.date.transferred2021-08-23T07:30:48Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=BioMed%20Research%20International&amp;rft.date=2021-05-24&amp;rft.volume=2021&amp;rft.spage=9957112&amp;rft.epage=9957112&amp;rft.eissn=2314-6133%20(Print)&amp;rft.issn=2314-6133%20(Print)&amp;rft.au=MASSONGO,%20M.&amp;NGANDO,%20L.&amp;PEFURA%20YONE,%20E.%20W.&amp;NZOUANKEU,%20A.&amp;MBANZOUEN,%20W.&amp;rft.genre=article


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