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Quality of Life and Cost-Effectiveness Assessment of Radioiodine Ablation Strategies in Patients With Thyroid Cancer: Results From the Randomized Phase III ESTIMABL Trial

dc.contributor.authorBORGET, Isabelle
dc.contributor.authorBONASTRE, Julia
dc.contributor.authorCATARGI, Bogdan
dc.contributor.authorDEANDREIS, Desiree
dc.contributor.authorZERDOUD, Slimane
dc.contributor.authorRUSU, Daniela
dc.contributor.authorBARDET, Stephane
dc.contributor.authorLEENHARDT, Laurence
dc.contributor.authorBASTIE, Delphine
dc.contributor.authorSCHVARTZ, Claire
dc.contributor.authorVERA, Pierre
dc.contributor.authorMOREL, Olivier
dc.contributor.authorBENISVY, Daniele
dc.contributor.authorBOURNAUD, Claire
dc.contributor.authorBONICHON, Francoise
dc.contributor.authorKELLY, Antony
dc.contributor.authorTOUBERT, Marie-Elisabeth
dc.contributor.authorLEBOULLEUX, Sophie
dc.contributor.authorJOURNEAU, Florence
dc.contributor.authorBENHAMOU, Ellen
dc.contributor.authorSCHLUMBERGER, Martin
dc.date.accessioned2020-09-03T08:02:19Z
dc.date.available2020-09-03T08:02:19Z
dc.date.issued2015
dc.identifier.issn0732-183X
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11013
dc.description.abstractEnPurpose In the ESTIMABL phase III trial, the thyroid ablation rate was equivalent for the two thyroid-stimulating hormone (TSH) stimulation methods (thyroid hormone withdrawal [THW] and recombinant human TSH [rhTSH]) and the two iodine-131 (I-131) activities (1.1 or 3.7 GBq). The objectives of this article were to present health-related quality-of-life (HRQoL) results and a cost-effectiveness evaluation performed alongside this trial. Patients and Methods HRQoL and utility were longitudinally assessed, from random assignment to the follow-up visit at 8 +/- 2 months for the 752 patients with thyroid cancer, using the Short Form-36 and the EuroQoL-5D questionnaires, respectively. A cost-effectiveness analysis was performed from the societal perspective in the French context. Resource use (hospitalization for I-131 administration, rhTSH, sick leaves, and transportation) was collected prospectively. We used the net monetary benefit approach and computed cost-effectiveness acceptability curves for both TSH stimulation methods and I-131 activities. Sensitivity analyses of the costs of rhTSH were performed. Results At I-131 administration, THW caused a clinically significant deterioration of HRQoL, whereas HRQoL remained stable with rhTSH. This deterioration was transient with no difference 3 months later. rhTSH was more effective than THW in terms of quality-adjusted life-years (QALYs; +0.013 QALY/patient) but more expensive (+(sic)474/patient). The probability that rhTSH would be cost effective at a (sic)50,000/QALY threshold was 47% in France. The use of 1.1 GBq of I-131 instead of 3.7 GBq reduced per-patient costs by (sic)955 (US$1,018) but with slightly decreased efficacy (-0.007 QALY/patient). Conclusion rhTSH avoids the transient THW-induced deterioration of HRQoL but is unlikely to be cost effective at its current price. (C) 2015 by American Society of Clinical Oncology
dc.language.isoen
dc.title.enQuality of Life and Cost-Effectiveness Assessment of Radioiodine Ablation Strategies in Patients With Thyroid Cancer: Results From the Randomized Phase III ESTIMABL Trial
dc.typeArticle de revue
dc.identifier.doi10.1200/jco.2015.61.6722
dc.subject.halChimie/Matériaux
bordeaux.journalJournal of clinical oncology
bordeaux.page2885-+
bordeaux.volume33
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue26
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
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