Mostrar el registro sencillo del ítem

Influence of isomerism on recrystallization and cocrystallization induced by CO2 as an antisolvent

dc.contributor.authorHARSCOAT SCHIAVO, Christelle
dc.contributor.authorNEUROHR, C.
dc.contributor.authorLECOMTE, S.
dc.contributor.authorMARCHIVIE, M.
dc.contributor.authorSUBRA-PATERNAULT, P.
dc.date.accessioned2020-09-03T08:02:09Z
dc.date.available2020-09-03T08:02:09Z
dc.date.issued2015
dc.identifier.issn1466-8033
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10977
dc.description.abstractEnMicronization, polymorphism, and cocrystal formation are well-known strategies to modify the characteristics of pharmaceutical ingredients. In this work, recrystallization induced by compressed CO2 as an antisolvent was investigated as a new way to produce aminosalicylate (ASA) polymorphs and cocrystals. Three ASA isomers were first recrystallized as single species. Isomerism has a particular influence on the product characteristics. The 5-ASA isomer was produced as micrometric spherical crystals with improved flow properties but no change in the crystal lattice was observed. 3-ASA recrystallized as micrometric spheres in a less dense crystal packing than that of the raw compound, and the 4-ASA isomer did not exhibit noticeable changes in the morphology or crystal lattice. Cocrystallization of each isomer with nicotinamide resulted in the production of an ASA:NCTA cocrystal only in the case of 4-ASA.
dc.language.isoen
dc.title.enInfluence of isomerism on recrystallization and cocrystallization induced by CO2 as an antisolvent
dc.typeArticle de revue
dc.identifier.doi10.1039/c5ce00753d
dc.subject.halChimie/Matériaux
bordeaux.journalCrystEngComm
bordeaux.page5410-5421
bordeaux.volume17
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue29
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=CrystEngComm&rft.date=2015&rft.volume=17&rft.issue=29&rft.spage=5410-5421&rft.epage=5410-5421&rft.eissn=1466-8033&rft.issn=1466-8033&rft.au=HARSCOAT%20SCHIAVO,%20Christelle&NEUROHR,%20C.&LECOMTE,%20S.&MARCHIVIE,%20M.&SUBRA-PATERNAULT,%20P.&rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem