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dc.rights.licenseopenen_US
dc.contributor.authorRACHEDI, K. O.
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorOUK, T. S.
dc.contributor.authorBAHADI, R.
dc.contributor.authorBOUZINA, A.
dc.contributor.authorDJOUAD, S. E.
dc.contributor.authorBECHLEM, K.
dc.contributor.authorZERROUKI, R.
dc.contributor.authorBEN HADDA, T.
dc.contributor.authorALMALKI, F.
dc.contributor.authorBERREDJEM, M.
dc.date.accessioned2021-07-16T14:31:04Z
dc.date.available2021-07-16T14:31:04Z
dc.date.issued2019
dc.identifier.issn0022-2860en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/109294
dc.description.abstractEnIn the present study, we investigated the cytotoxic activity of three compounds prepared starting from amino acids. These derivatives were evaluated for their in vitro antitumor activity against human cell lines (PRI, K562 and JURKAT). Their cytotoxicity was also evaluated at different concentrations on several cell lines. On the other hand, DFT calculation has been used to analyze the electronic and geometric characteristics. The HOMO, LUMO and gap energies were also deduced for the stable structure for each compound. These results will be correlated with the experimental values. The bioinformatic POM (Petra/Osiris/Molinspiration) analyses of the relative cytotoxicity of these derivatives are reported in comparison to Chlorambucil. (C) 2019 Published by Elsevier B.V.
dc.language.isoENen_US
dc.subject.enAmidophosphonate
dc.subject.enCytotoxicity activity
dc.subject.enDFT calculations
dc.subject.enDescriptors
dc.subject.enPOM analyses
dc.title.enSynthesis, DFT and POM analyses of cytotoxicity activity of alpha-camidophosphonates derivatives: Identification of potential antiviral O,O-pharmacophore site
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.molstruc.2019.07.053en_US
dc.subject.halChimie/Matériauxen_US
bordeaux.journalJournal of Molecular Structureen_US
bordeaux.page196-203en_US
bordeaux.volume1197en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03289141
hal.version1
hal.date.transferred2021-07-16T14:31:07Z
hal.exporttrue
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