Pro-drug peptide with improved pharmaceutical properties
| dc.contributor.author | ZIMMER, Robert H. | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | GUICHARD, Gilles
IDREF: 084339268 | |
| dc.contributor.author | FREMAUX, Juliette | |
| dc.contributor.author | VENIN, Claire | |
| dc.contributor.author | GOUDREAU, Sebastien | |
| dc.date.accessioned | 2021-07-16T14:24:08Z | |
| dc.date.available | 2021-07-16T14:24:08Z | |
| dc.date.issued | 2019 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/109287 | |
| dc.description.abstractEn | The present disclosure relates to a pro-drug peptide, or a salt thereof, having improvement for at least one biological property relative to a parent peptide or peptidomimetic, wherein the biological property is selected from the group consisting of therapeutic index, stability, solubility, toxicity, adsorption, and pre-systemic metabolism. The pro-drug peptide comprising the following structure: Z-pep, wherein: pep is the parent peptide or peptidomimetic; Z is a sequence of n amino acids, Z is cleaved in vivo releasing pep; n≥2 amino acids. The present disclosure also relates to methods of making and using the pro-drug peptide of the present disclosure. For example, the present disclosure describes a pro-drug peptide that may be used to prevent, treat, or ameliorate at least one symptom of hypoglycemia or a hypoglycemia-related disease or disorder. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Pro-drug peptide with improved pharmaceutical properties | |
| dc.type | Brevet | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.country | fr | |
| bordeaux.brevet.number | US20190002519 | en_US |
| hal.identifier | hal-03431572 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-11-16T16:35:34Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2019&rft.au=ZIMMER,%20Robert%20H.&GUICHARD,%20Gilles&FREMAUX,%20Juliette&VENIN,%20Claire&GOUDREAU,%20Sebastien&rft.genre=unknown |
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