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Encapsulation of epsilon-viniferin in onion-type multi-lamellar liposomes increases its solubility and its photo-stability and decreases its cytotoxicity on Caco-2 intestinal cells

dc.rights.licenseopenen_US
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorCOURTOIS, Arnaud
IDREF: 092021301
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorGARCIA, Mathieu
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorKRISA, Stephanie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorATGIE, Claude
IDREF: 097463213
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorSAUVANT, Patrick
ORCID: 0000-0002-2562-9185
IDREF: 118627325
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorRICHARD, Tristan
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorFAURE, Chrystel
dc.date.accessioned2021-07-15T13:01:08Z
dc.date.available2021-07-15T13:01:08Z
dc.date.issued2019
dc.identifier.issn2042-6496en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/109260
dc.description.abstractEnepsilon-Viniferin, a resveratrol dimer, is a naturally occurring stilbene that has been studied so far for its potential beneficial effects on human health. Its low water solubility, its photo-sensitivity and its low bioavailability make its applications in the food industry complicated. To overcome these limitations, epsilon-viniferin was encapsulated in phospholipid-based multi-lamellar liposomes (MLLs) called spherulites or onions. In the best case, an encapsulation efficiency of 58 +/- 3% and a bioactive loading of 4.2 +/- 0.5% were reached. Encapsulation of epsilon-viniferin drastically increased its water solubility by more than 5 orders to reach 17.4 g L-1 and provided protection against its UV-induced isomerization. While epsilon-viniferin was shown to be significantly toxic to Caco-2 intestinal-like cells for concentrations higher than 25 M, once encapsulated in MLLs, those cells did not experience any mortality even for the highest tested stilbene concentration (100 M) as revealed by red neutral assay.
dc.language.isoENen_US
dc.title.enEncapsulation of epsilon-viniferin in onion-type multi-lamellar liposomes increases its solubility and its photo-stability and decreases its cytotoxicity on Caco-2 intestinal cells
dc.typeArticle de revueen_US
dc.identifier.doi10.1039/c9fo00420cen_US
dc.subject.halChimie/Matériauxen_US
bordeaux.journalFood & Functionen_US
bordeaux.page2573-2582en_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionBordeaux Sciences Agroen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Food%20&%20Function&rft.date=2019&rft.volume=10&rft.issue=5&rft.spage=2573-2582&rft.epage=2573-2582&rft.eissn=2042-6496&rft.issn=2042-6496&rft.au=COURTOIS,%20Arnaud&GARCIA,%20Mathieu&KRISA,%20Stephanie&ATGIE,%20Claude&SAUVANT,%20Patrick&rft.genre=article


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