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Monitoring the Interactions of a Ternary Complex Using NMR Spectroscopy: The Case of Sugars, Polyphenols, and Proteins

dc.contributor.authorFAURIE, Benoit
dc.contributor.authorDUFOURC, Erick J.
dc.contributor.authorLAGUERRE, Michel
dc.contributor.authorPIANET, Isabelle
dc.date.accessioned2020-09-03T07:56:19Z
dc.date.available2020-09-03T07:56:19Z
dc.date.issued2016
dc.identifier.issn0003-2700
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10874
dc.description.abstractEnGaining insight into intermolecular interactions between multiple species is possible at an atomic level by looking at different parameters using different NMR techniques. In the specific case of the astringency sensation, in which at least three molecular species are involved, different NMR. techniques combined with dynamic light scattering and molecular modeling contribute to decipher the role of each component in the interaction mode and to assess the thermodynamic parameters governing this complex interaction. The binding process between a saliva peptide, a polyphenol, and polysaccharides was monitored by following H-1 chemical shift variations, changes in NMR peak areas, and size of the formed complex. These NMR experiments deliver a complete picture of the association pathway, assessed by dynamic light scattering and molecular dynamics simulations: all of the data collected converge toward a comprehensive mode of interaction in which sugars indirectly play a role in astringency by sequestering part of the polyphenols, reducing their effective concentration to bind saliva proteins.
dc.language.isoen
dc.title.enMonitoring the Interactions of a Ternary Complex Using NMR Spectroscopy: The Case of Sugars, Polyphenols, and Proteins
dc.typeArticle de revue
dc.subject.halChimie/Matériaux
bordeaux.journalAnalytical Chemistry
bordeaux.page12470-12478
bordeaux.volume88
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue24
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Analytical%20Chemistry&rft.date=2016&rft.volume=88&rft.issue=24&rft.spage=12470-12478&rft.epage=12470-12478&rft.eissn=0003-2700&rft.issn=0003-2700&rft.au=FAURIE,%20Benoit&DUFOURC,%20Erick%20J.&LAGUERRE,%20Michel&PIANET,%20Isabelle&rft.genre=article


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