LE SAUX, Guillaume; PLAWINSKI, Laurent; NLATE, Sylvain; RIPOCHE, Jean; BUFFETEAU, Thierry; DURRIEU, Marie-Christine

doi:10.1371/journal.pone.0150706

Metadatos

Mostrar el registro completo del ítem

Licencia de uso del documento

Idioma

Article de revue

Este ítem está publicado en

Plos One. 2016, vol. 11, n° 3

Resumen en inglés

Intravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical challenge. Herein we report on the production and the characterization of gold surfaces covalently derivatized with the peptide alpha-alpha-melanocyte stimulating hormone (alpha-MSH), with a quantifiable surface density. In vitro study demonstrated that the tethered alpha-MSH is able to decrease the expression of an inflammatory cytokine produced by endothelial cells.< Leer menos

Metadatos

Compartir este ítem

Licencia de uso del documento

Beneficial Effect of Covalently Grafted alpha-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices

Idioma

Este ítem está publicado en

Resumen en inglés

URI

DOI

Centros de investigación