Afficher la notice abrégée

Blood pressure and cognitive performances in middle-aged adults: the Aging, Health and Work longitudinal study

dc.rights.licenseopenen_US
dc.contributor.authorROUCH, L.
dc.contributor.authorCESTAC, P.
dc.contributor.authorHANON, O.
dc.contributor.authorRUIDAVETS, J. B.
dc.contributor.authorEHLINGER, V.
dc.contributor.authorGENTIL, C.
dc.contributor.authorCOOL, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
dc.contributor.authorBOUHANICK, B.
dc.contributor.authorCHAMONTIN, B.
dc.contributor.authorSALLERIN, B.
dc.contributor.authorVELLAS, B.
dc.contributor.authorMARQUIE, J. C.
dc.contributor.authorESQUIROL, Y.
dc.contributor.authorANDRIEU, S.
dc.date.accessioned2020-07-24T09:04:10Z
dc.date.available2020-07-24T09:04:10Z
dc.date.issued2019-06
dc.identifier.issn1473-5598 (Electronic) 0263-6352 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10669
dc.description.abstractEnBACKGROUND: Our objective was to investigate the impact of both prevalent and incident hypertension on cognition in middle-aged individuals followed up for 10 years and to explore the extent to which blood pressure control by antihypertensive drugs could modify this relationship. METHOD: Three thousand, two hundred and one participants from the Vieillissement Sante Travail (Aging, Health and Work) (VISAT) cohort study, aged 32, 42, 52 and 62 years at baseline were followed up 5 and 10 years later. Blood pressure, antihypertensive medication use as well as memory and speed cognitive performances were assessed at baseline and follow-up. Linear mixed models were used for analyses. RESULTS: At 10-year follow-up, compared with nonhypertensive participants, prevalent hypertensive individuals showed poorer global cognitive performances (beta = -2.99 +/- 0.96, P = 0.002 for participants aged 32 or 42 years at baseline and beta = -5.94 +/- 1.00, P < 0.001 for those aged 52 or 62). Patients with incident hypertension had poorer global cognitive performances over time compared with patients without hypertension. When considering prevalent hypertension and blood pressure control status by antihypertensive therapy, untreated and uncontrolled hypertension were associated with poorer cognitive performances than controlled and no hypertension (untreated hypertension compared with no hypertension: beta = -5.51 +/- 0.75, P < 0.001; uncontrolled hypertension compared with no hypertension: beta = -6.13 +/- 1.40, P < 0.001). CONCLUSION: Our findings showed that both prevalent and incident hypertension are associated with poorer global cognitive function in middle-aged individuals and suggested a potential preventive effect of antihypertensive therapy on cognition. Thus, for brain functioning, heightened efforts to detect hypertension and adequately treat it are of critical importance.
dc.language.isoENen_US
dc.subject.enLEHA
dc.subject.enSEPIA
dc.title.enBlood pressure and cognitive performances in middle-aged adults: the Aging, Health and Work longitudinal study
dc.title.alternativeJ Hypertensen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/HJH.0000000000002013en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30624363en_US
bordeaux.journalJournal of Hypertensionen_US
bordeaux.page1244-1253en_US
bordeaux.volume37en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03163745
hal.version1
hal.date.transferred2021-03-09T13:26:28Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Hypertension&amp;rft.date=2019-06&amp;rft.volume=37&amp;rft.issue=6&amp;rft.spage=1244-1253&amp;rft.epage=1244-1253&amp;rft.eissn=1473-5598%20(Electronic)%200263-6352%20(Linking)&amp;rft.issn=1473-5598%20(Electronic)%200263-6352%20(Linking)&amp;rft.au=ROUCH,%20L.&amp;CESTAC,%20P.&amp;HANON,%20O.&amp;RUIDAVETS,%20J.%20B.&amp;EHLINGER,%20V.&amp;rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée