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Nurses' internal contamination by antineoplastic drugs in hospital centers: a cross-sectional descriptive study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorVILLA, Antoine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOLIMARD, Mathieu
dc.contributor.authorSAKR, Dunia
dc.contributor.authorLASSALLE, Regis
dc.contributor.authorBIGNON, Emmanuelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMARTINEZ, Beatrice
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUYER, Magali
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMATHOULIN-PELISSIER, Simone
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALDI, Isabelle
dc.contributor.authorVERDUN-ESQUER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCANAL-RAFFIN, Mireille
dc.date.accessioned2021-07-09T12:17:26Z
dc.date.available2021-07-09T12:17:26Z
dc.date.issued2021-05-22
dc.identifier.issn0340-0131en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/106490
dc.description.abstractEnOBJECTIVE: The aim of this study was to assess internal antineoplastic drugs (ADs) contamination in the nursing staff in French hospital centers, using highly sensitive analytical methods. METHODS: This cross-sectional study included nurses practicing in care departments where at least one of the five ADs studied was handled (5-fluorouracil, cyclophosphamide, doxorubicin, ifosfamide, methotrexate). The nurses study participation lasted 24 h including collection of three urine samples and one self-questionnaire. All urine samples were assayed by ultra-high-performance liquid chromatography-tandem mass spectrometry methods with very low value of the lower limit of quantification (LLOQ). RESULTS: 74 nurses were included, 222 urine samples and 74 self-questionnaires were collected; 1092 urine assays were performed. The percentage of nurses with internal AD contamination was 60.8% and low levels of urinary concentrations were measured. Regarding nurses with internal contamination (n = 45), 42.2% presented internal contamination by methotrexate, 37.8% by cyclophosphamide, 33.3% by ifosfamide, 17.8% by 5-fluorouracil metabolite and 6.7% by doxorubicine. Among the positive assays, 17.9% (n = 26/145) were not explained by exposure data from the self-questionnaire but this could be due to the skin contact of nurses with contaminated work surfaces. CONCLUSIONS: This study reported high percentage of nurses with internal ADs contamination. The low LLOQ values of the used analytical methods, allowed the detection of ADs that would not have been detected with the current published methods: the percentage of contamination would have been 17.6% instead of the 60.8% reported here. Pending toxicological reference values, urine ADs concentrations should be reduced as low as reasonably achievable (ALARA principle).
dc.language.isoENen_US
dc.subject.enBiomonitoring
dc.subject.enUrine analysis
dc.subject.enAntineoplastic drugs
dc.subject.enOccupational exposure
dc.subject.enInternal contamination
dc.subject.enNurses
dc.title.enNurses' internal contamination by antineoplastic drugs in hospital centers: a cross-sectional descriptive study
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00420-021-01706-xen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34021808en_US
bordeaux.journalInternational Archives of Occupational and Environmental Healthen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPH
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03282809
hal.version1
hal.date.transferred2021-07-09T12:17:29Z
hal.exporttrue
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