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A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

dc.rights.licenseopenen_US
dc.contributor.authorVAN DER LEE, S. J.
dc.contributor.authorKNOL, M. J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHAUHAN, Ganesh
dc.contributor.authorSATIZABAL, C. L.
dc.contributor.authorSMITH, A. V.
dc.contributor.authorHOFER, E.
dc.contributor.authorBIS, J. C.
dc.contributor.authorHIBAR, D. P.
dc.contributor.authorHILAL, S.
dc.contributor.authorVAN DEN AKKER, E. B.
dc.contributor.authorARFANAKIS, K.
dc.contributor.authorBERNARD, M.
dc.contributor.authorYANEK, L. R.
dc.contributor.authorAMIN, N.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCRIVELLO, F.
dc.contributor.authorCHEUNG, J. W.
dc.contributor.authorHARRIS, T. B.
dc.contributor.authorSABA, Y.
dc.contributor.authorLOPEZ, O. L.
dc.contributor.authorLI, S.
dc.contributor.authorVAN DER GROND, J.
dc.contributor.authorYU, L.
dc.contributor.authorPAUS, T.
dc.contributor.authorROSHCHUPKIN, G. V.
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorJAHANSHAD, N.
dc.contributor.authorTAYLOR, K. D.
dc.contributor.authorYANG, Q.
dc.contributor.authorMATHIAS, R. A.
dc.contributor.authorBOEHRINGER, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMAZOYER, Bernard
dc.contributor.authorRICE, K.
dc.contributor.authorCHENG, C. Y.
dc.contributor.authorMAILLARD, P.
dc.contributor.authorVAN HEEMST, D.
dc.contributor.authorWONG, T. Y.
dc.contributor.authorNIESSEN, W. J.
dc.contributor.authorBEISER, A. S.
dc.contributor.authorBEEKMAN, M.
dc.contributor.authorZHAO, W.
dc.contributor.authorNYQUIST, P. A.
dc.contributor.authorCHEN, C.
dc.contributor.authorLAUNER, L. J.
dc.contributor.authorPSATY, B. M.
dc.contributor.authorIKRAM, M. K.
dc.contributor.authorVERNOOIJ, M. W.
dc.contributor.authorSCHMIDT, H.
dc.contributor.authorPAUSOVA, Z.
dc.contributor.authorBECKER, D. M.
dc.contributor.authorDE JAGER, P. L.
dc.contributor.authorTHOMPSON, P. M.
dc.contributor.authorVAN DUIJN, C. M.
dc.contributor.authorBENNETT, D. A.
dc.contributor.authorSLAGBOOM, P. E.
dc.contributor.authorSCHMIDT, R.
dc.contributor.authorLONGSTRETH, W. T.
dc.contributor.authorIKRAM, M. A.
dc.contributor.authorSESHADRI, Sudha
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorGUDNASON, V.
dc.contributor.authorADAMS, H. H. H.
dc.contributor.authorDECARLI, C.
dc.date.accessioned2020-07-16T10:26:15Z
dc.date.available2020-07-16T10:26:15Z
dc.date.issued2019-08-02
dc.identifier.issn2399-3642en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10491
dc.description.abstractEnBrain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial volume. Two loci, associated with occipital (6q22.32) and temporal lobe volume (12q14.3), were previously reported to associate with intracranial and hippocampal volume, respectively. We identified four loci previously unknown to affect brain volumes: 3q24 for parietal lobe volume, and 1q22, 4p16.3 and 14q23.1 for occipital lobe volume. The associated variants were located in regions enriched for histone modifications (DAAM1 and THBS3), or close to genes causing Mendelian brain-related diseases (ZIC4 and FGFRL1). No genetic overlap between lobar volumes and neurological or psychiatric diseases was observed. Our findings reveal part of the complex genetics underlying brain development and suggest a role for regulatory regions in determining brain volumes.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/
dc.subject.enVINTAGE
dc.title.enA genome-wide association study identifies genetic loci associated with specific lobar brain volumes
dc.title.alternativeCommun Biolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s42003-019-0537-9en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31396565en_US
bordeaux.journalCommunications biologyen_US
bordeaux.page285en_US
bordeaux.volume2en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGE
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Communications%20biology&rft.date=2019-08-02&rft.volume=2&rft.spage=285&rft.epage=285&rft.eissn=2399-3642&rft.issn=2399-3642&rft.au=VAN%20DER%20LEE,%20S.%20J.&KNOL,%20M.%20J.&CHAUHAN,%20Ganesh&SATIZABAL,%20C.%20L.&SMITH,%20A.%20V.&rft.genre=article


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