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Occupational exposure to pesticides and multiple myeloma in the AGRICAN cohort

dc.rights.licenseopenen_US
dc.contributor.authorTUAL, S.
dc.contributor.authorBUSSON, A.
dc.contributor.authorBOULANGER, M.
dc.contributor.authorRENIER, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPIEL, Clement
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPOUCHIEU, Camille
dc.contributor.authorPONS, R.
dc.contributor.authorPERRIER, S.
dc.contributor.authorLEVEQUE-MORLAIS, N.
dc.contributor.authorKARURANGA, P.
dc.contributor.authorLEMARCHAND, C.
dc.contributor.authorMARCOTULLIO, E.
dc.contributor.authorGUIZARD, A. V.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONNEREAU, Alain
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALDI, Isabelle
dc.contributor.authorLEBAILLY, Pierre
dc.date.accessioned2020-07-16T09:46:00Z
dc.date.available2020-07-16T09:46:00Z
dc.date.issued2019-11
dc.identifier.issn1573-7225 (Electronic) 0957-5243 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10485
dc.description.abstractEnPURPOSE: Epidemiological studies have found an increased risk of multiple myeloma (MM) in farmers. Few studies have investigated the detailed circumstances of occupational pesticide exposure which could explain these increased risks (pesticide use on crops, seeds or on animals, contact with treated crops) and the role of other exposures. In the Agriculture and Cancer cohort (AGRICAN), we assessed the associations between MM and crop- or animal-related activities, with specific attention to pesticide exposure via use on animals and crops or contact with treated crops and to disinfectant exposure. METHODS: Analyses concerned 155,192 participants, including 269 incident MM identified by cancer registries from enrolment (2005-2007) to 2013. Cox models using attained age as time scale were run to calculate hazard ratios (HR) and 95% confidence intervals (CI). RESULTS: MM risk was increased in farmers (i) who started using pesticides on crops in the 1960s, especially among those applying pesticides on corn (>/= 20 years: HR 1.73, 95% CI 1.08, 2.78, p for trend < 0.01) and (ii) using insecticides on animals (HR 1.48, 95% CI 1.11, 1.98), especially among horse farmers (>/= 10 years: HR 2.77, 95% CI 1.22-6.27, p for trend = 0.01). We also observed significant elevated risks with disinfectant use in animal barns. CONCLUSIONS: Findings support the role of pesticide use on crops and animals in the occurrence of MM risk in farmers.
dc.language.isoENen_US
dc.subject.enEPICENE
dc.title.enOccupational exposure to pesticides and multiple myeloma in the AGRICAN cohort
dc.title.alternativeCancer Causes Controlen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s10552-019-01230-xen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31535326en_US
bordeaux.journalCancer causes & controlen_US
bordeaux.page1243-1250en_US
bordeaux.volume30en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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